Compare DULOXETINE (DULOXETINE HYDROCHLORIDE) and PREGABALIN (PREGABALIN) — clinical data, side effects, and patient experiences.
DULOXETINE HYDROCHLORIDE, Cymbalta · SNRI
How it works
12.1 Mechanism of Action Although the exact mechanisms of the antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are ...
Approved for
PREGABALIN, Lyrica, Alzain · Anticonvulsant
How it works
Other agent
Approved for
Estimated frequency (%) based on clinical trial data
Based on 27 Reddit discussions
DULOXETINE
27%
positive
15 threads
PREGABALIN
25%
positive
12 threads
% of discussions mentioning each side effect
15 Reddit threads analysed for DULOXETINE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
43 upvotes
Most discussed side effects in community
I am a 28 year old man and I've just realized that nothing interests me. I believe that it might be connected to depression as I am on medication for depression and anxiety (duloxetine) I am not really sad or anything. I am just very neutral. Things that used to interest, excite me and make me happ
I have been recovering from over a decade of major depressive disorder and recently diagnosed bipolar II. I’m seeing light at the end of the tunnel with Lamotrigine and lifestyle changes, and after several mental health evaluations, my psychiatrist gave me the best news ever; I can stop taking antid
Hi, just wondering if this is a common experience: So i've been taking agomelatine 50mg for about 5 months and duloxetine 60mg for 3 months now for severe depression and anxiety. The antidepressants have been working just as intended in the sense that most of the mental agony has gone, but there's
I ( M23) have been taking duloxetine 60 mg for 2 years now. While it has helped tremendously with my anxiety/depression/DPDR, it did cause sexual side effects for me. (I also take lamotrigine, but that is unlikely to cause effects like this) For me, these sides were very annoying; my main problem wa
Entry time 8:55am Before I went to sleep last night, I had nurses come 2 times, around 9:30pm and then at 10:40pm asking if I wanted to take some anxiety medication to help me sleep better. I refused both times as it wasn't initially prescribed, and in general I don't have a problem sleeping. My al
UHC is canceling coverage of my medication: Lamotrigine, Atomoxetine, and Duloxetine. Starts in January. Im barely getting by as it is. I need to find new insurance asap (Im in the USA). Its no wonder they were targeted. I just learned that they deny the most coverage of any US health insurer. Wtf a
Since the late of 2019 year, till now I've tried: 1- Escitalopram "Lexapro" (tried Atomoxetine "Strattera" with it, then stopped it due to its bad effects) (tried Risperidone "Rispardal" then stopped it, it hasn't only bad effects, but also highly increased prolactin) 2- Fluoxetine "Prozac" 3- Bupro
You know how a lot of sources say working towards a goal and then achieving it gives a sense of reward via dopamine? This week I got a pay rise, achieved a fitness goal I've been working towards for months and even got asked out on a date by someone quite attractive. But I feel absolutely nothing.
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
12 Reddit threads analysed for PREGABALIN
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
234 upvotes
Most discussed side effects in community
6 years ago I broke my knee playing rugby. I was 33. I had a fair bit of metal put in and lots and lots of rehab. 2 years on crutches and over 4 years of physio. Nothing helped the pain and they removed the metal, which also didn’t help. I had a nerve block injection and was told it may stop the pai
In 2018 I started having daily headaches, it was in my temples, eyebrows/forehead and neck/occipital. I was bedridden for 6 years, unable to work, study, clean my own bedroom or even watching something on TV. I've taken every possible migraine medication: topiramate, emgality, amitriptyline, pregaba
The Italian Society for Rheumatology (SIR) has developed 17 recommendations for the diagnosis and management of fibromyalgia syndrome (FMS), emphasizing a comprehensive, individualized, and evidence-based approach. Below is a summary of these recommendations: 1. Comprehensive Evaluation: FMS manage
I've had to move back home due to the cost of living be so high and my mum has taken my dihydrocodeine from me. She says I take it everyday and am addicted. She says that I should just take paracetamo and be on a pain patch. I'm only taking my dihydrocodeine as prescribed for my slipped discs and p
25F just recently diagnosed so I went to the pharmacy to pick up pregabalin prescribed by my rheumatologist. Of course I hadn’t taken it before so I asked the pharmacist to go over it with me. He asks “what’s it for”? I say “fibromyalgia” then the comments of “wow you’re pretty young for that”. I gu
Title says all. I was recently diagnosed with fibro after testing negative for other autoimmune and muscle diseases. However I seem to have a unique version where I experience 24/7 muscle stiffness and inflammation. Being a little risqué, it feels like I'm tightly wrapped up in BDSM-type rope all ov
I started with 1.5mg and slowly worked my way to 4.5mg, going up 0.5mg at a time. Since the very first dose, I noticed a decrease in pain. With every single dose increase, the pain relief got better and better. When I hit 3.5mg, I had ZERO pain the next day during my 8 hours of work. That’s right -
Just a vent post really. Why is every single medical appointment such a fucking fight every time to advocate for myself and be heard??? Like even with pain management doctors who are supposed to want to help people like me. I literally asked about pregabalin because we haven’t really tried many me
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
DULOXETINE is a SNRI, while PREGABALIN belongs to the Anticonvulsant class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
Both medications are approved for See full prescribing information. When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.
DULOXETINE carries 4 FDA warnings. PREGABALIN carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.
Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.