Is DrugNote medical advice?

No. DrugNote is an independent reference site that aggregates FDA label data, FAERS reports, clinical studies, and public patient discussions. It is for informational use only and is not a substitute for advice from a qualified clinician.

Where does DrugNote source its data?

Drug profiles come from openFDA and DailyMed, side-effect frequency from the FDA Adverse Event Reporting System (FAERS), study references from ClinicalTrials.gov and PubMed, and patient voices from public Reddit threads. See /sources/ for the full provenance trail.

How is DrugNote different from drugs.com or WebMD?

DrugNote is built around head-to-head comparisons rather than single-drug encyclopedias. Every page pairs clinical label data with real patient discussion side by side, attributed to the original subreddit and post.

Does DrugNote accept payment from drug manufacturers?

No. DrugNote is ad-free and does not accept paid placement or sponsored content from manufacturers.

A medication reference for people, not pharmacies

Two drugs.
The real story.

Compare medications side by side — clinical trial data on one side, what real patients are saying on the other. Built for the person who just got switched to a biosimilar and needs answers tonight.

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2,204Medications indexed

5,210Head-to-head comparisons

6Patient discussions analysed

DailyFDA label refresh

§01 — Browse

Comparisons people are actually running this week.

Drawn from search volume and patient discussion analysis. Click any pair to see clinical data, side-effect profiles, and what patients are saying.

Type 2 Diabetes

Metforminvs.Sitagliptin

First-line generic biguanide vs. once-daily DPP-4 inhibitor. GI tolerability is the swing factor.

1,420 threadsA 72%+ · B 64%+

Read the comparison →

Hypertension

Lisinoprilvs.Losartan

ACE inhibitor vs. ARB — the cough switch. Both effective; tolerability differs sharply by patient.

2,108 threadsA 61%+ · B 78%+

Read the comparison →

Cholesterol — Statins

Atorvastatinvs.Rosuvastatin

Two high-intensity statins compared on LDL reduction, muscle tolerability, and drug interactions.

1,683 threadsA 68%+ · B 71%+

Read the comparison →

SSRI — Depression & Anxiety

Escitalopramvs.Sertraline

The two most-prescribed SSRIs head to head. Activation, sleep, weight, sexual side-effects compared.

3,512 threadsA 74%+ · B 69%+

Read the comparison →

Antibiotic — Respiratory

Amoxicillinvs.Azithromycin

Penicillin vs. macrolide for sinus, ear, and chest infections. Resistance patterns and GI side-effects.

942 threadsA 70%+ · B 65%+

Read the comparison →

Reflux — PPI

Omeprazolevs.Pantoprazole

Long-term reflux management. Bioavailability, interactions, and rebound on discontinuation.

1,257 threadsA 66%+ · B 72%+

Read the comparison →

§02 — Voices

The information drug labels leave out.

What does the injection actually feel like? Did the fatigue ever go away? Does the biosimilar really work like the brand? We index public discussions so the answers are easier to find.

Ulcerative colitis

“Switched from Humira to Cyltezo on the insurance push. First two injections felt sharper, then identical. Three months in, my labs haven't moved — I think this is just Humira with a different label.”

u/ibd_dad·412 upvotes·r/UlcerativeColitis · 3w

Ankylosing spondylitis

“The citrate-free formulation is the actual difference. The original Humira sting is gone. I almost cancelled my switch in panic — wish someone had told me this beforehand.”

u/AS_runner_31·287 upvotes·r/ankylosingspondylitis · 6w

Psoriatic arthritis

“Three weeks on the biosimilar. Joints flared briefly week two then settled. Rheum says that's a transition blip, not the drug failing. Holding steady.”

u/PsA_mom·164 upvotes·r/PsoriaticArthritis · 2w

Type 2 diabetes

“Came off Januvia because of joint pain — turns out it's a known DPP-4 side effect not on the patient label. Wish I'd searched for real stories first.”

u/sugar_steady·523 upvotes·r/diabetes_t2 · 4w

Major depression

“Switched from Lexapro to Zoloft. Activation week one was rough — I thought I was getting worse. By week four it lifted. The taper-and-cross matters more than the drug.”

u/quietly_okay·342 upvotes·r/antidepressants · 5w

All patient voices are sourced from public Reddit threads. Posts are de-identified beyond the subreddit. Content reflects individual opinions and is not medical advice.

§03 — By condition

Start with what you’re treating.

Most patients arrive at DrugNote because their treatment just changed. Browse by indication to find the comparisons that matter to your therapy.

01Rheumatoid arthritisRA→02Ulcerative colitis & Crohn'sUC / Crohn's→03Psoriasis & psoriatic arthritisPsO / PsA→04Type 2 diabetesT2D→05HypertensionHigh blood pressure→06Depression & anxietyMDD / GAD→07GERD & refluxGERD→08Migraine & chronic painMigraine→

§04 — Request

Can’t find your medication?

We add new drugs within 48 hours, prioritised by community requests. Tell us what you’re looking for — we’ll email you when it’s live.

Two drugs.The real story.

Comparisons people are actually running this week.

The information drug labels leave out.

Start with what you’re treating.

Can’t find your medication?

Two drugs.The real story.

Comparisons people are actually running this week.

The information drug labels leave out.

Start with what you’re treating.

Can’t find your medication?

Two drugs.
The real story.

Two drugs.
The real story.