Compare Lisinopril (Zestril) and Losartan (Cozaar) — clinical data, side effects, and patient experiences.
Zestril, Prinivil · ACE Inhibitor
How it works
Inhibits angiotensin-converting enzyme (ACE), preventing conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, leading to decreased blood pressure and reduced al...
Approved for
Cozaar · ARB (Angiotensin II Receptor Blocker)
How it works
Selectively blocks the binding of angiotensin II to the AT1 receptor found in many tissues, reducing vasoconstriction, aldosterone secretion, and sympathetic activity.
Approved for
Estimated frequency (%) based on clinical trial data
Based on 16 Reddit discussions
Lisinopril
67%
positive
6 threads
Losartan
10%
positive
10 threads
% of discussions mentioning each side effect
6 Reddit threads analysed for Lisinopril
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
46 upvotes
Most discussed side effects in community
I wanted to share my experience in case it helps someone who might be in the same confusing situation I was in. I’m a **46 year old male,** fairly active, healthy weight, and generally careful with my lifestyle. About a year and a half ago, I started paying closer attention to my blood pressure, whi
Just wanted to share my story of getting my BP under control as motivation for all of us who struggle with it. I am 46 yo, fit and athletic individual (155lbs, distance runner, scuba diver) who had a reasonably good diet and mild alcohol use. During a regular health checkup, my BP was very high and
I've been dealing with high blood pressure for 6-7 years now, back in 2020 it was as high as 160/110, and no meds helped me until I finally went on 40 mg of Lisinopril and 12.5 mg of HCTZ. Last year I got into a minor car accident and they incidentally found a small tumor on my left adrenal gland. T
I have had stage two hypertension for almost a decade now, at age 37. It's mostly my regular body so it hasn't been possible to reach normal levels without meds. I was on 5 mg Lisinopril and 5 mg of amlodopine for a while, but after losing weight and exercising I was able to go off amlodopine. But t
I went to the doctor today to be seen for retina problems arising from high blood pressure..but, when they took my blood pressure (I have been on beetroot for about a month now), they said my blood pressure was 100/68? I could not believe it, I thought they were going to give me lisinopril or someth
Losing hope For the sake of brevity, I’ll leave out a long story that goes with this. 35 male other wise healthy Treatment resistant hypertension with PVCs and tachycardia since 18 years of age. On 4-5 BP meds nothing really works. Renal artery scan - nothing Aldosterone abnormalities - none Adrena
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
10 Reddit threads analysed for Losartan
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
51 upvotes
Most discussed side effects in community
Today went to see my cardiologist and no longer need to take losartan nor atorvastatin ! Got to a healthy weight and good diet that he said I no longer need the medication. Hopefully I can stay off it from now on. Im 5,8 went from 225lbs down to 185, eating a lot of food with high sodium to no/low
Hi, how is it going. Today I'm officially off blood pressure meds completely. With lifestyle changes, low sodium diet, low sugar, aerobic exercise and weight loss. I had blood pressure in the 170 to 180 systolic in January of 2025 after heart surgery on November 2024. I was 230 pounds and am current
I take 100 mg of Losartan daily, but before meds I was easily in the 140-150/90-100 range. Even after taking medication I was usually in the 130/90+ range. My resting heart rate used to sit at about 110 too. I felt like shit and my bod was so tense. But recently I stopped drinking and smoking and be
My blood pressure (seemingly) started giving me problems beginning of this year and I was put on losartan 50mg. I take that once a day and it seems to control my BP well (below 130/80). However, in the 4 months I've been on this medication, I've noticed when I'm on my period, my blood pressure shoot
Just felt compelled to write my positive experience with amlodipine. I've had high blood pressure for about 3-4 years. Average wasn't anything crazy, but around 150-160/90. I was prescribed 50 mg if Losartan, which seemed to do nothing. But I've been in it for the last 2 years. Finally, I decided Lo
I am a 35 year old male, recently diagnosed with stage 1 borderline stage 2 hypertension, my doc started me on 50 mg Losartan right away. I have a history of depression and anxiety and have tried Celexa, Lexapro, before finally settling in on Wellbutrin for a few years now, which has kept my normal
25m. I visited the doctor 2 months ago and was diagnosed with high bp and was put on 50mg Losartan. Was usually in the 150s/90 for the first week then it slowly worked but after my monthly visit back my doctor didn’t like the numbers so my dosage was doubled to 100mg. After 1 and a half months of lo
26m, started losartan in February and up until about 2 months ago it’s been goin great. I was exercising and eating right and doing everything i could to keep bp stead around the 120/80, when i last checked my bp about 2 months ago it was in that range.. These past 2 months I’ve been going through a
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Lisinopril is a ACE Inhibitor, while Losartan belongs to the ARB (Angiotensin II Receptor Blocker) class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles. Lisinopril has a half-life of 12 hours, compared to 2 hours (active metabolite: 6-9 hours) for Losartan. A longer half-life may allow for less frequent dosing but can also mean side effects persist longer.
Both medications are approved for Hypertension. When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.
Lisinopril carries 2 FDA warnings. Losartan carries 1 FDA warning. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
There is 1 clinical study directly comparing Lisinopril and Losartan. Head-to-head trial data provides the strongest evidence for comparative effectiveness, though study design, endpoints, and patient populations should be considered when interpreting results.
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.
Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.