Compare LIRAGLUTIDE (Liraglutide) and TIRZEPATIDE (Zepbound) — clinical data, side effects, and patient experiences.
Liraglutide, Victoza, Saxenda · GLP-1 Agonist
How it works
12.1 Mechanism of Action Liraglutide is an acylated human GLP-1 receptor agonist with 97% amino acid sequence homology to endogenous human GLP-1(7 to 37). GLP-1(7 to 37) represents...
Approved for
Zepbound, ZEPBOUND, Zepbound KwikPen · GLP-1 / GIP Agonist
How it works
12.1 Mechanism of Action Tirzepatide is a GIP receptor and GLP-1 receptor agonist. It contains a C20 fatty diacid that enables albumin binding and prolongs the half-life. Tirzepati...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 26 Reddit discussions
LIRAGLUTIDE
21%
positive
14 threads
TIRZEPATIDE
42%
positive
12 threads
% of discussions mentioning each side effect
14 Reddit threads analysed for LIRAGLUTIDE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
9 upvotes
Most discussed side effects in community
After two consecutive blood tests showed and A1C of 4.5-4.6, my primary care physician had me drop my T2 meds. I achieved these results through diet and exercise, supported by my meds. First he had me drop Jardiance, and that went fine. Another 4.6 A1C. Then he had me drop Victoza/Liraglutide and Me
Slight cross post from a r/KaiserPermanente thread of mine. After 2 years and 4 denials to see an endocrinologist as an uncontrolled T2D, I finally got them to accept the referral after asking for a formal denial letter so I could go self-pay to an out of network hospital system a few counties away.
I was diagnosed with T2 back in November and it gave me a scare. I’m in the morbidly obese category and on liraglutide to help. I don’t think it’s working well for me but that’s a separate issue. I feel like I need another kick, I haven’t received a lot of support from my GP (in the UK) and I am try
Hi all I’ve been diagnosed type 2 this January and have since been on a mix of metformin, glimepiride, and sitagliptin none of which lowered my sugars very much. My nurse has suggested that I could go onto a daily or weekly injection (Liraglutide/Trulicity) to help stimulate the insulin levels. Does
When I was first diagnosed, I couldn’t afford my medications to keep everything maintained. My A1C is sitting somewhere around a 7/8. Two years later, I moved to 12u long acting and around 20-30u of fast acting. Doctor tried to put me on Ozempic, but I ended up in the ER from an allergic reaction.
For the past 5 months I have been working really hard on my diet and fitness level where i've pretty much got it in lock down. I've integrated healthy eating and going into the gym in a very sustainable way where it's a part of me now. It is kind of surreal to think now there were days on end I woul
It works by helping the pancreas to release the right amount of insulin when blood sugar levels are high. Liraglutide injection also slows the emptying of the stomach and may decrease appetite and cause weight loss. It's been a couple of days and I'm having some trouble with nausea. I've found that
Hey everyone. Quick disclaimer that I do not have T2D (though was pre-T2D a few years ago). I understand that internet advice cannot substitute for medical professionals' words, but I was hoping if others in /r/diabetes have had success with dealing with a situation like my father's. He was diagnos
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
12 Reddit threads analysed for TIRZEPATIDE
Overall Sentiment
Mixed
Comparison Threads
1
Avg Post Score
15 upvotes
Most discussed side effects in community
Threads directly comparing TIRZEPATIDE to other medications
Update.. my uncontrolled T2 is now under control. I’ve decided to take Mounjaro and I no longer have crazy spikes. So far no side effects. Hey everyone! 👋 My doctor recently gave me two options to help lower my A1C—Ozempic and Mounjaro (Tirzepatide). I’d love to hear from anyone who’s taken either
Recently diagnosed type 2. Have been on metformin since December 1. Have lost about 10 pounds with it but the diarrhea is too much for my system, and i was only at 1000mg extended release once a day. Doc told me to discontinue metformin. Was then contacted by the “weight management” team. They t
It’s amazing how life can turn on a dime. Last week, I was bummed because I had a check up and expected to see improvement in my A1C (blood sugar) after 10 weeks on tirzepatide. Instead, it had shot up into diabetic range. I felt pretty overwhelmed thinking about how I was going to manage yet anothe
So I was diagnosed as diabetic at the beginning of this month. My doctor has been useless. He called me to tell me my blood work showed diabetes and to take metformin for three months and then see him again. That was it. He didn't even tell me what my a1c was or anything. He prescribed me tirzepatid
I am so frustrated! I have been on Mounjaro 12.5mg for about 18 months now, having titrated up from 10mg. I transferred to Mounjaro because Trulicity was not having the same impact as the Ozempic, which I was forced to swap to after my insurance company changed their formulary and Ozempic stopped
I just started this meditation 3 weeks ago so far so good my sugar levels are dropping and no metformin yay 😀 if I loose any weight it will be a bonus I’m currently on 2.5 has anyone dropped weight on this mg ?
Pretty much the post title. For those taking a GLP-1 medication, especially those who are well controlled, has taking a GLP-1 allowed you to feel less paranoid about what you eat? For context, Dx T2 last year with A1C of 7.1, potential LADA dx in Feb (C peptide is solidly normal). 1000mg of metformi
Like many people, the pandemic hit me hard—but not just emotionally. During lockdown, I found myself turning to food for comfort. The weight crept on until I reached 14 stone 10 lbs. At just 5'3", I felt heavy, sluggish, and uncomfortable. To put it into perspective, the last time I’d been close to
My dad is 70 and we need help. He has just about everything wrong with him, kidney disease, high blood pressure, congestive heart failure(unsure of the stage, but I would guess rather advanced, diabetes for 30 years, COPD(thankfully has stopped smoking). He's been battling this fluid build up that
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
LIRAGLUTIDE is a GLP-1 Agonist, while TIRZEPATIDE belongs to the GLP-1 / GIP Agonist class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
Both medications are approved for See full prescribing information. When two drugs treat the same condition, the choice between them often depends on the patient's medical history, other medications, tolerability, and prescriber preference.
LIRAGLUTIDE carries 4 FDA warnings. TIRZEPATIDE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.
Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.