Compare Semaglutide (Ozempic) and TOPIRAMATE (Topiramate) — clinical data, side effects, and patient experiences.
Ozempic, Wegovy, Rybelsus · GLP-1 Agonist
How it works
Glucagon-like peptide-1 (GLP-1) receptor agonist with 94% homology to human GLP-1. Stimulates insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite c...
Approved for
Topiramate, Topamax · Anticonvulsant
How it works
12.1 Mechanism of Action The precise mechanisms by which topiramate exerts its anticonvulsant and preventive migraine effects are unknown; however, preclinical studies have reveale...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 25 Reddit discussions
Semaglutide
36%
positive
11 threads
TOPIRAMATE
21%
positive
14 threads
% of discussions mentioning each side effect
11 Reddit threads analysed for Semaglutide
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
30 upvotes
Most discussed side effects in community
I was diagnosed back at the end of March this year and I was very sick. My A1C was 14! Blood sugars of 300+ average. I took this very seriously as I had seen what type 1 did to my grandma. And I know type 1 and type 2 are two very different beasts, I did not want to have to give myself insulin as we
I am new diagnosed type 2 diabetic. My fasting bs was 140 and A1C is 6.4. My insurance denied both tirzepitide and Semaglutide brand names stating my A1C must be 6.5. I’m so frustrated. I had started taking compounded Semaglutide prior to my diagnosis for weight loss and then did my blood work and r
**1st June 2021 - new docs, start treatment** weight: **216 lb** / 97.98 kg height: 6'1" / 1.85 m BMI: 28.5 (overweight) BP: **132/90** (too high) *start lisinopril* HbA1c: **10.4%** average BG: 252 mg/dL, 14 mmol/L LDL: 127 mg/dL HDL: 36 mg/dL TG: 845 mg/dL (!)
I have been using ozempic for 3 months. My side effects were mild and bearable. I noticed that I got nausea when I ate unhealthy or large amounts of food. I started to eat less and better quality. I was more sensitive to motion nausea (like long bus rides), but all ok. Last month my period was
I was diagnosed with T2 in April 2024 after having symptoms like thirsty and weight loss . My A1C was 11.5 in April .after taking medications and vigorous workouts , A1C dropped to 5.5 in October . I trained for marathon and ran Chicago marathon . I put in lot of miles . I am not strict on diet tho
Well... I had a good run, but Ozempic has finally become Unobtainium where I live, and my endo seems intent on waiting a couple of days to get back to me to say that they sent a refill to a pharmacy that doesn't have it to sell. I'm supposed to take a 2 mg shot today, and my next endo appointment is
Hi guys, Happy New Year! I was diagnosed with T2 about a year ago, but I struggled taking care of myself. I was depressed and didn't really think about it too much, therefore, I was still eating a lot of junk food, staying all day in the couch but I was always feeling tired and my health wasn't the
Hi everyone. My husband (33) was recently diagnosed with type 2 diabetes and I am a feeling a broad mix of emotions. We got married this year, I'm a deeply anxious person, and it just made me jump straight to worst case scenarios. So it's been a hard couple of days and I don't think I'm making it an
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
14 Reddit threads analysed for TOPIRAMATE
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
16 upvotes
Most discussed side effects in community
# General Info An Anticonvulsant may be used as a mood stabilizer to treat mood disorders characterized by intense and sustained mood shifts, typically Bipolar Disorder. Mood stabilizers suppress swings between mania and depression. The oldest and most studied mood stabilizer is [Lithium](https://ww
Hi all, I know this is a common question/topic of discussion here but I’m so frustrated and I’m looking for any help. I’m currently on 1200 lithium and 150 lamictal. Started 50 topiramate once a night 3 1/2 weeks ago, have seen no results, no change in appetite, nothing. I was diagnosed a year ago
So my husband turned 28 today. It's his first birthday since we got married, his first birthday in years when all our friends can hang out, he has the day off, we have our own place, and generally everything is good. Only problem is that this morning I woke up with my mania coming to a screeching ha
Hi everyone, if you’re reading this, thank you. From the deepest I can, I appreciate you. I ***finally*** got my diagnosis on the 30th of September after many years of confusion, seeing multiple counselors, therapists, doctors and psychiatrists. Earlier in the month I voluntarily spent a week in th
Hey all! I started noticing significant shedding of my hair about six months after upping my dose of topiramate to 75 mg/day. It seemed to get worse when I switched generic brands to Teva and right now about 2/3 of my hair is gone. Literally clumps were falling out on my floors and I was cleaning
It’s a mixture of bad choices influenced by a depression episode and reasons out of my control. I was fit last summer during a hypomanic episode then I went through a following depression episode last fall/winter and gained 30lb through binge eating. Hovered there. Then got meds adjusted to change t
As of late I have found it very hard to get out of the house. I can get up, shower, eat but when it finally comes time to leave; I just can’t. Going to the store is no problem, but getting out to go do something is seemingly impossible. I’ve recently went under some pretty drastic medication changes
I was prescribed it in the hospital because they didn’t think I was taking the lithium even though I was and they thought I was allergic to lamictal even though I’m not, and I refuse to take depakote, so they went with topamax, but I don’t hear of anyone taking topamax as a mood stabilizer. Everyone
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Semaglutide is a GLP-1 Agonist, while TOPIRAMATE belongs to the Anticonvulsant class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles. Semaglutide is administered via Subcutaneous or Oral, whereas TOPIRAMATE uses Oral. Route of administration can affect onset of action and patient adherence.
Semaglutide carries 3 FDA warnings. TOPIRAMATE carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.
Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.