Is Spironolactone and Hydrochlorothiazide the same as Triamterene and Hydrochlorothiazide?

No. Spironolactone and Hydrochlorothiazide (SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE) and Triamterene and Hydrochlorothiazide (TRIAMTERENE AND HYDROCHLOROTHIAZIDE) are distinct medications. They are sometimes confused because of similar branding or because they treat overlapping conditions, but they have different active ingredients and different safety profiles.

Which has fewer side effects, SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE or TRIAMTERENE AND HYDROCHLOROTHIAZIDE?

Side-effect frequency varies by individual. The side-effect comparison section on this page shows FAERS-reported events for each drug side by side. FAERS is voluntary reporting, so it reflects what patients and clinicians chose to report, not absolute population risk.

Can I switch from SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE to TRIAMTERENE AND HYDROCHLOROTHIAZIDE?

Switching medications should always be done under prescriber supervision. The "patient stories" section on this page includes accounts from people who have made the switch and what their transition felt like, but those are individual experiences, not protocols.

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE vs TRIAMTERENE AND HYDROCHLOROTHIAZIDE

Compare SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE (Spironolactone and Hydrochlorothiazide) and TRIAMTERENE AND HYDROCHLOROTHIAZIDE (Triamterene and Hydrochlorothiazide) — clinical data, side effects, and patient experiences.

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE

Spironolactone and Hydrochlorothiazide · Thiazide Diuretic

How it works

Mechanism of action Spironolactone and hydrochlorothiazide tablets are a combination of two diuretic agents with different but complementary mechanisms and sites of action, thereby...

Approved for

INDICATIONS AND USAGE Spironolactone

an ingredient of spironolactone and hydrochlorothiazide tablets

or is intolerant of

other therapeutic measures

OralTablet

TRIAMTERENE AND HYDROCHLOROTHIAZIDE

Triamterene and Hydrochlorothiazide · Thiazide Diuretic

How it works

Thiazide Diuretic agent

Approved for

patients on concomitant digitalis preparations

or with a history of cardiac arrhythmias

etc.). Triamterene and hydrochlorothiazide may be used alone or in combination with other antihypertensive drugs

such as beta-blockers. Since triamterene and hydrochlorothiazide may enhance the actions of these drugs

OralTablet

Quick Comparison

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDETRIAMTERENE AND HYDROCHLOROTHIAZIDE

Drug Class

Thiazide Diuretic

Route

Oral

Half-Life

—

FDA Approved

—

Side Effect Frequency Comparison

Estimated frequency (%) based on clinical trial data

Side Effects

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE

Shortness of Breath

>10%

Fatigue

1-10%

Nausea

1-10%

Diarrhea

1-10%

Dizziness

1-10%

Headache

1-10%

Low Blood Pressure

1-10%

Drug Not Working

1-10%

TRIAMTERENE AND HYDROCHLOROTHIAZIDE

Fatigue

1-10%

Drug Not Working

1-10%

Nausea

1-10%

Diarrhea

1-10%

Dizziness

1-10%

Shortness of Breath

1-10%

Headache

1-10%

Weakness

1-10%

FDA Warnings

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE

WARNINGS Potassium supplementation, either in the form of medication or as a diet rich in potassium, should not ordinarily be given in association with spironolactone and hydrochlorothiazide therapy
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy

TRIAMTERENE AND HYDROCHLOROTHIAZIDE

WARNINGS: Hyperkalemia: Abnormal elevation of serum potassium levels (greater than or equal to 5
Since uncorrected hyperkalemia may be fatal, serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide, when dosages are changed or with any illness that may influence renal function

Clinical Trial Data

No head-to-head clinical studies found for SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE vs TRIAMTERENE AND HYDROCHLOROTHIAZIDE.

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE vs TRIAMTERENE AND HYDROCHLOROTHIAZIDE: What You Should Know

Key Differences

Both SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE and TRIAMTERENE AND HYDROCHLOROTHIAZIDE belong to the Thiazide Diuretic class. While they share a similar mechanism of action, differences in pharmacokinetics, dosing, and side effect profiles may make one more suitable than the other for individual patients.

Safety Considerations

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE carries 2 FDA warnings. TRIAMTERENE AND HYDROCHLOROTHIAZIDE carries 2 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..

This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.

Related Comparisons

LISINOPRIL AND HYDROCHLOROTHIAZIDE TABLETS vs TRIAMTERENE AND HYDROCHLOROTHIAZIDE→LISINOPRIL AND HYDROCHLOROTHIAZIDE vs TRIAMTERENE AND HYDROCHLOROTHIAZIDE→CHLORTHALIDONE vs TRIAMTERENE AND HYDROCHLOROTHIAZIDE→OLMESARTAN MEDOXOMIL-HYDROCHLOROTHIAZIDE vs TRIAMTERENE AND HYDROCHLOROTHIAZIDE→HYDROCHLOROTHIAZIDE vs TRIAMTERENE AND HYDROCHLOROTHIAZIDE→OLMESARTAN MEDOXOMIL AND HYDROCHLOROTHIAZIDE vs TRIAMTERENE AND HYDROCHLOROTHIAZIDE→

Primary sources

Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE: DailyMed label · FAERS adverse events · ClinicalTrials.gov
TRIAMTERENE AND HYDROCHLOROTHIAZIDE: DailyMed label · FAERS adverse events · ClinicalTrials.gov

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SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE vs TRIAMTERENE AND HYDROCHLOROTHIAZIDE

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE

Spironolactone and Hydrochlorothiazide · Thiazide Diuretic

How it works

Mechanism of action Spironolactone and hydrochlorothiazide tablets are a combination of two diuretic agents with different but complementary mechanisms and sites of action, thereby...

Approved for

INDICATIONS AND USAGE Spironolactone

an ingredient of spironolactone and hydrochlorothiazide tablets

or is intolerant of

other therapeutic measures

OralTablet

TRIAMTERENE AND HYDROCHLOROTHIAZIDE

Triamterene and Hydrochlorothiazide · Thiazide Diuretic

How it works

Thiazide Diuretic agent

Approved for

patients on concomitant digitalis preparations

or with a history of cardiac arrhythmias

etc.). Triamterene and hydrochlorothiazide may be used alone or in combination with other antihypertensive drugs

such as beta-blockers. Since triamterene and hydrochlorothiazide may enhance the actions of these drugs

OralTablet

Quick Comparison

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDETRIAMTERENE AND HYDROCHLOROTHIAZIDE

Drug Class

Thiazide Diuretic

Route

Oral

Half-Life

—

FDA Approved

—

Side Effect Frequency Comparison

Estimated frequency (%) based on clinical trial data

Side Effects

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE

Shortness of Breath

>10%

Fatigue

1-10%

Nausea

1-10%

Diarrhea

1-10%

Dizziness

1-10%

Headache

1-10%

Low Blood Pressure

1-10%

Drug Not Working

1-10%

TRIAMTERENE AND HYDROCHLOROTHIAZIDE

Fatigue

1-10%

Drug Not Working

1-10%

Nausea

1-10%

Diarrhea

1-10%

Dizziness

1-10%

Shortness of Breath

1-10%

Headache

1-10%

Weakness

1-10%

FDA Warnings

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE

WARNINGS Potassium supplementation, either in the form of medication or as a diet rich in potassium, should not ordinarily be given in association with spironolactone and hydrochlorothiazide therapy
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy

TRIAMTERENE AND HYDROCHLOROTHIAZIDE

WARNINGS: Hyperkalemia: Abnormal elevation of serum potassium levels (greater than or equal to 5
Since uncorrected hyperkalemia may be fatal, serum potassium levels must be monitored at frequent intervals especially in patients first receiving triamterene and hydrochlorothiazide, when dosages are changed or with any illness that may influence renal function

Clinical Trial Data

No head-to-head clinical studies found for SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE vs TRIAMTERENE AND HYDROCHLOROTHIAZIDE.

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE vs TRIAMTERENE AND HYDROCHLOROTHIAZIDE: What You Should Know

Key Differences

Safety Considerations

This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.

Primary sources

Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.

SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE: DailyMed label · FAERS adverse events · ClinicalTrials.gov
TRIAMTERENE AND HYDROCHLOROTHIAZIDE: DailyMed label · FAERS adverse events · ClinicalTrials.gov