Question 1

What is ABATACEPT used for?

Accepted Answer

ABATACEPT (brand name ORENCIA) is a Other indicated for in combination with a calcineurin inhibitor and methotrexate, biologic disease-modifying antirheumatic drugs (bDMARDS), Janus kinase (JAK) inhibitors] is not recommended. ( 1.5.

Question 2

How does ABATACEPT work?

Accepted Answer

ABATACEPT works through the following mechanism: 12.1 Mechanism of Action Abatacept, a selective costimulation modulator, inhibits T-cell (T lymphocyte) activation by binding to CD80 and CD86, thereby blocking interaction with CD28. This interaction provides a costimulatory signal necessary for full activation of T lymphocytes. Activated T lymphocytes are implicated in the pathogenesis of RA, pJIA and PsA and are found in the synovium of patients with RA, pJIA and PsA. In vitro , abatacept decreases T-cell proliferation and inhibits the production of the cytokines TNF alpha (TNFα), interferon-γ, and interleukin-2. In a rat collagen-induced arthritis model, abatacept suppresses inflammation, decreases anti-collagen antibody production, and reduces antigen specific production of interferon-γ. The relationship of these biological response markers to the mechanisms by which ORENCIA exerts its clinical effects is unknown..

Question 3

What are the most common side effects of ABATACEPT?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for ABATACEPT. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is ABATACEPT the same as ORENCIA?

Accepted Answer

ORENCIA is a brand name for ABATACEPT. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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