Question 1

What is ABIRATERONE ACETATE used for?

Accepted Answer

ABIRATERONE ACETATE (brand name Abiraterone Acetate) is a Other indicated for See full prescribing information.

Question 2

How does ABIRATERONE ACETATE work?

Accepted Answer

ABIRATERONE ACETATE works through the following mechanism: 12.1 Mechanism of Action Abiraterone acetate is converted in vivo to abiraterone, an androgen biosynthesis inhibitor, that inhibits 17 α-hydroxylase/C17,20-lyase (CYP17). This enzyme is expressed in testicular, adrenal, and prostatic tumor tissues and is required for androgen biosynthesis. CYP17 catalyzes two sequential reactions: 1) the conversion of pregnenolone and progesterone to their 17α-hydroxy derivatives by 17α-hydroxylase activity and 2) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by C17, 20 lyase activity. DHEA and androstenedione are androgens and are precursors of testosterone. Inhibition of CYP17 by abiraterone can also result in increased mineralocorticoid production by the adrenals [see Warnings and Precautions ( 5.1 )]. Androgen sensitive prostatic carcinoma responds to treatment that decreases androgen levels. Androgen deprivation therapies, such as treatment with GnRH agonists or orchiectomy, decrease androgen producti.

Question 3

What are the most common side effects of ABIRATERONE ACETATE?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for ABIRATERONE ACETATE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is ABIRATERONE ACETATE the same as Abiraterone Acetate?

Accepted Answer

Abiraterone Acetate is a brand name for ABIRATERONE ACETATE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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