Question 1

What is ACOLTREMON used for?

Accepted Answer

ACOLTREMON (brand name TRYPTYR) is a Other indicated for See full prescribing information.

Question 2

How does ACOLTREMON work?

Accepted Answer

ACOLTREMON works through the following mechanism: 12.1 Mechanism of Action Studies in animals suggest that acoltremon, the active substance in TRYPTYR, is an agonist of transient receptor potential melastatin 8 (TRPM8) thermoreceptors. TRPM8 thermoreceptor stimulation has been shown to activate trigeminal nerve signaling leading to increased basal tear production. The exact mechanism of action for TRYPTYR in dry eye disease is unknown..

Question 3

What are the most common side effects of ACOLTREMON?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for ACOLTREMON. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is ACOLTREMON the same as TRYPTYR?

Accepted Answer

TRYPTYR is a brand name for ACOLTREMON. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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