Question 1

What is ADAPALENE used for?

Accepted Answer

ADAPALENE (brand name Adapalene) is a Retinoid indicated for INDICATIONS AND USAGE: Adapalene cream is indicated for the topical treatment of acne vulgaris..

Question 2

How does ADAPALENE work?

Accepted Answer

ADAPALENE works through the following mechanism: Mechanism of Action: Adapalene acts on retinoid receptors. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. Mechanistically, adapalene binds to specific retinoic acid nuclear receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene normalizes the differentiation of follicular epithelial cells resulting in decreased microcomedone formation..

Question 3

What are the most common side effects of ADAPALENE?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for ADAPALENE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is ADAPALENE the same as Adapalene?

Accepted Answer

Adapalene is a brand name for ADAPALENE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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