Question 1

What is ALECTINIB HYDROCHLORIDE used for?

Accepted Answer

ALECTINIB HYDROCHLORIDE (brand name ALECENSA) is a Electrolyte / Mineral indicated for See full prescribing information.

Question 2

How does ALECTINIB HYDROCHLORIDE work?

Accepted Answer

ALECTINIB HYDROCHLORIDE works through the following mechanism: 12.1 Mechanism of Action Alectinib is a tyrosine kinase inhibitor that targets ALK and RET. In nonclinical studies, alectinib inhibited ALK phosphorylation and ALK-mediated activation of the downstream signaling proteins STAT3 and AKT, and decreased tumor cell viability in multiple cell lines harboring ALK fusions, amplifications, or activating mutations. The major active metabolite of alectinib, M4, showed similar in vitro potency and activity. Alectinib and M4 demonstrated in vitro and in vivo activity against multiple mutant forms of the ALK enzyme, including some mutations identified in NSCLC tumors in patients who have progressed on crizotinib. In mouse models implanted with tumors carrying ALK fusions, administration of alectinib resulted in antitumor activity and prolonged survival, including in mouse models implanted intracranially with ALK-driven tumor cell lines..

Question 3

What are the most common side effects of ALECTINIB HYDROCHLORIDE?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for ALECTINIB HYDROCHLORIDE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is ALECTINIB HYDROCHLORIDE the same as ALECENSA?

Accepted Answer

ALECENSA is a brand name for ALECTINIB HYDROCHLORIDE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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