Question 1

What is ALITRETINOIN used for?

Accepted Answer

ALITRETINOIN (brand name PANRETIN) is a Retinoid indicated for symptomatic lymphedema, symptomatic pulmonary KS.

Question 2

How does ALITRETINOIN work?

Accepted Answer

ALITRETINOIN works through the following mechanism: 12.1 Mechanism of Action Alitretinoin (9-cis-retinoic acid) is a naturally occurring endogenous retinoid that binds to and activates all known intracellular retinoid receptor subtypes (RARα, RARβ, RARγ, RXRα, RXRβ and RXRγ). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells. Alitretinoin inhibits the growth of Kaposi’s sarcoma (KS) cells in vitro..

Question 3

What are the most common side effects of ALITRETINOIN?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for ALITRETINOIN. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is ALITRETINOIN the same as PANRETIN?

Accepted Answer

PANRETIN is a brand name for ALITRETINOIN. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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