12.1. Mechanism of Action CPD Mechanism of Action CITRATE PHOSPHATE DEXTROSE acts as an extracorporeal anticoagulant by binding the free calcium in the blood. Calcium is a necessary co-factor to several steps in the clotting cascade. The following ingredients are key components of the solution: Citric Acid for pH regulation Sodium Citrate functions as an anticoagulant Dextrose for isotonicity Sodium Dihydrogen Phosphate for pH buffering This solution has no clinical effect in transfused patients. AS-5 Mechanism of Action ADDITIVE SOLUTION FORMULA 5 acts to preserve and extend the shelf life of packed RBC products for later transfusion to patients. The following ingredients are key components of the solution: Dextrose for RBC nutrition Sodium Chloride for isotonicity Mannitol to protect RBC membranes Adenine to support adenosine triphosphate (ATP) levels This solution has no clinical effect in transfused patients.
Contraindications
4 documented side effects by frequency
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Dosage Forms
Tablet
Route
Oral