Question 1

What is BEROTRALSTAT HYDROCHLORIDE used for?

Accepted Answer

BEROTRALSTAT HYDROCHLORIDE (brand name Orladeyo) is a Electrolyte / Mineral indicated for See full prescribing information.

Question 2

How does BEROTRALSTAT HYDROCHLORIDE work?

Accepted Answer

BEROTRALSTAT HYDROCHLORIDE works through the following mechanism: 12.1 Mechanism of Action Berotralstat is a plasma kallikrein inhibitor that binds to plasma kallikrein and inhibits its proteolytic activity. Plasma kallikrein is a protease that cleaves high-molecular-weight kininogen (HMWK) to generate cleaved HMWK (cHMWK) and bradykinin, a potent vasodilator that increases vascular permeability resulting in swelling and pain associated with HAE. In patients with HAE due to C1-inhibitor (C1-INH) deficiency or dysfunction, normal regulation of plasma kallikrein activity is not present, which leads to uncontrolled increases in plasma kallikrein activity and results in angioedema attacks. Berotralstat decreases plasma kallikrein activity to control excess bradykinin generation in patients with HAE..

Question 3

What are the most common side effects of BEROTRALSTAT HYDROCHLORIDE?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for BEROTRALSTAT HYDROCHLORIDE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is BEROTRALSTAT HYDROCHLORIDE the same as Orladeyo?

Accepted Answer

Orladeyo is a brand name for BEROTRALSTAT HYDROCHLORIDE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

BEROTRALSTAT HYDROCHLORIDE

Mechanism of Action

Indications

FDA Warnings

Known Side Effects

Community Discussions

Primary sources

Compare With

Formulations