Question 1

What is BEXAROTENE used for?

Accepted Answer

BEXAROTENE (brand name Targretin) is a Other indicated for See full prescribing information.

Question 2

How does BEXAROTENE work?

Accepted Answer

BEXAROTENE works through the following mechanism: 12.1 Mechanism of Action Bexarotene selectively binds and activates retinoid X receptor subtypes (RXRα, RXRß, RXRγ). RXRs can form heterodimers with various receptor partners such as retinoic acid receptors (RARs), vitamin D receptor, thyroid receptor, and peroxisome proliferator activator receptors (PPARs). Once activated, these receptors function as transcription factors that regulate the expression of genes that control cellular differentiation and proliferation. Bexarotene inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin. It also induces tumor regression in vivo in some animal models. The exact mechanism of action of bexarotene in the treatment of cutaneous T-cell lymphoma (CTCL) is unknown..

Question 3

What are the most common side effects of BEXAROTENE?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for BEXAROTENE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is BEXAROTENE the same as Targretin?

Accepted Answer

Targretin is a brand name for BEXAROTENE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

BEXAROTENE

Mechanism of Action

Indications

FDA Warnings

Known Side Effects

Community Discussions

Primary sources

Compare With

Formulations