What are the most common side effects of BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE the same as its brand-name version?

BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE is the generic name. The active ingredient is the same across any brand-name or generic versions approved by the FDA.

BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE

Q: What is BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE used for?

BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE is a Opioid Analgesic indicated for a partial opioid agonist, and naloxone, an opioid antagonist.

Q: How does BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE work?

BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE works through the following mechanism: 12.1 Mechanism of Action ZUBSOLV contains buprenorphine and naloxone. Buprenorphine is a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor. Naloxone is a potent antagonist at mu-opioid receptors and produces opioid withdrawal signs and symptoms, if administered parenterally, in individuals physically dependent on full opioid agonists..

Opioid Analgesic

Sublingual

Mechanism of Action

12.1 Mechanism of Action ZUBSOLV contains buprenorphine and naloxone. Buprenorphine is a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor. Naloxone is a potent antagonist at mu-opioid receptors and produces opioid withdrawal signs and symptoms, if administered parenterally, in individuals physically dependent on full opioid agonists.

Indications

a partial opioid agonist

and naloxone

an opioid antagonist

and is indicated for treatment of opioid dependence. ( 1 ) ZUBSOLV should be used as part of a complete treatment plan that includes counseling and psychosocial support. ( 1 )

Contraindications

• 4 CONTRAINDICATIONS ZUBSOLV is contraindicated in patients with a history of hypersensitivity to buprenorphine or naloxone as serious adverse reactions
• including anaphylactic shock
• have been reported [see Warnings and Precautions ( 5.9 )]. Hypersensitivity to buprenorphine or naloxone. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Addiction, Abuse, and Misuse : Buprenorphine can be abused in a similar manner to other opioids
1 ) Respiratory Depression : Life-threatening respiratory depression and death have occurred in association with buprenorphine use
Buprenorphine can cause severe and fatal respiratory depression in children
6 ) Risk of Opioid Withdrawal with Abrupt Discontinuation: If treatment is temporarily interrupted or discontinued, monitor patients for withdrawal and treat appropriately

Known Side Effects

5 documented side effects by frequency

Drug Not Working

1-10%

Nausea

1-10%

Vomiting

0.1-1%

Headache

0.1-1%

Dizziness

0.1-1%

Community Discussions

1 Reddit threads analysed for BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE

Overall Sentiment

Slightly negative

Comparison Threads

Avg Post Score

11 upvotes

Most discussed side effects in community

Nausea (1)

Insomnia (1)

Anxiety (1)

Stomach Pain (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

When will this cycle end ... asking for a friend ...

Doug was addicted to pain meds, and then used Suboxone to get off the pain meds/opiates, but then continued the Suboxone use for a significant number of years and became dependent on the usage, still afraid to go off of it, back into addiction or experience withdrawal. So now he's using a liquid-whi

r/Jamienotis11182y ago

Nausea

Insomnia

Anxiety

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE openFDA label JSON → BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE FAERS adverse-event reports → BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE ClinicalTrials.gov → completed Phase 2+ trials of BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE

Compare With

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Formulations

Dosage Forms

Tablet

Route

Sublingual