Question 1

What is BUROSUMAB used for?

Accepted Answer

BUROSUMAB (brand name CRYSVITA) is a Other indicated for See full prescribing information.

Question 2

How does BUROSUMAB work?

Accepted Answer

BUROSUMAB works through the following mechanism: 12.1 Mechanism of Action X-linked hypophosphatemia is caused by excess fibroblast growth factor 23 (FGF23) which suppresses renal tubular phosphate reabsorption and the renal production of 1,25 dihydroxy vitamin D. Burosumab-twza binds to and inhibits the biological activity of FGF23 restoring renal phosphate reabsorption and increasing the serum concentration of 1,25 dihydroxy vitamin D..

Question 3

What are the most common side effects of BUROSUMAB?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for BUROSUMAB. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is BUROSUMAB the same as CRYSVITA?

Accepted Answer

CRYSVITA is a brand name for BUROSUMAB. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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