Brand names: candesartan cilexetil and hydrochlorothiazide
Mechanism of Action Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT 1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is, therefore, independent of the pathways for angiotensin II synthesis. There is also an AT 2 receptor found in many tissues, but AT 2 is not known to be associated with cardiovascular homeostasis. Candesartan has much greater affinity (>10,000-fold) for the AT 1 receptor than for the AT 2 receptor. Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit th
Contraindications
13 documented side effects by frequency
2 Reddit threads analysed for CANDESARTAN CILEXETIL AND HYDROCHLOROTHIAZIDE
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Most discussed side effects in community
**Age and Gender:** 75 years old, female. **Height and Weight:** 150 cm, 50 kg. **Smoking Status:** Non-smoker. Good morning everyone, I am writing to seek advice on managing my 75-year-old mother’s therapy, as she has a rather complex medical history. In 2015, she underwent a biolog
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Dosage Forms
Tablet
Route
Oral