How does CASPOFUNGIN ACETATE work?

CASPOFUNGIN ACETATE works through the following mechanism: 12.1 Mechanism of Action Caspofungin is an echinocandin antifungal drug [see Microbiology ( 12.4 )]..

What are the most common side effects of CASPOFUNGIN ACETATE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for CASPOFUNGIN ACETATE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is CASPOFUNGIN ACETATE the same as Caspofungin Acetate?

Caspofungin Acetate is a brand name for CASPOFUNGIN ACETATE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

CASPOFUNGIN ACETATE

Q: What is CASPOFUNGIN ACETATE used for?

CASPOFUNGIN ACETATE (brand name Caspofungin Acetate) is a Antifungal indicated for neutropenic patients. ( 1 ) Treatment of candidemia and the following Candida infections: intra-abdominal abscesses, Neutropenic Patients Caspofungin acetate for injection is indicated as empirical therapy for presumed fungal infections in febrile, neutropenic adult and pediatric patients (3 months of age and older) [see Clinical Studies ( 14.1.

Antifungal

Brand names: Caspofungin Acetate

Intravenous

Mechanism of Action

12.1 Mechanism of Action Caspofungin is an echinocandin antifungal drug [see Microbiology ( 12.4 )].

Indications

neutropenic patients. ( 1 ) Treatment of candidemia and the following Candida infections: intra-abdominal abscesses

Neutropenic Patients Caspofungin acetate for injection is indicated as empirical therapy for presumed fungal infections in febrile

neutropenic adult and pediatric patients (3 months of age and older) [see Clinical Studies ( 14.1

peritonitis

and pleural space infections in adult and pediatric patients (3 months of age and older) [see Clinical Studies ( 14.2

14.5 )] . Limitations of Use : Caspofungin acetate for injection has not been studied in endocarditis

Contraindications

• 4 CONTRAINDICATIONS Caspofungin is contraindicated in patients with known hypersensitivity (e.g.
• anaphylaxis) to any component of this product [see Adverse Reactions ( 6 )]. Caspofungin is contraindicated in patients with known hypersensitivity to any component of this product. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Hypersensitivity : Anaphylaxis, possible histamine-mediated adverse reactions, including rash, facial swelling, angioedema, pruritus, sensation of warmth or bronchospasm, and cases of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been reported with use of caspofungin
Monitor patients who develop abnormal liver enzymes for evidence of worsening hepatic function, and evaluate risk/benefit of continuing caspofungin
2 ) Elevated Liver Enzymes During Concomitant Use with Cyclosporine : Limit use to patients for whom potential benefit outweighs potential risk
Cases of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), some with a fatal outcome, have been reported with use of caspofungin [see Adverse Reactions ( 6

Known Side Effects

2 documented side effects by frequency

Drug Not Working

>10%

Fever

1-10%

Community Discussions

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Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → CASPOFUNGIN ACETATE openFDA label JSON → CASPOFUNGIN ACETATE FAERS adverse-event reports → CASPOFUNGIN ACETATE ClinicalTrials.gov → completed Phase 2+ trials of CASPOFUNGIN ACETATE

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Formulations

Dosage Forms

Tablet

Route

Intravenous