Question 1

What is CROFELEMER used for?

Accepted Answer

CROFELEMER (brand name MYTESI) is a Other indicated for See full prescribing information.

Question 2

How does CROFELEMER work?

Accepted Answer

CROFELEMER works through the following mechanism: 12.1 Mechanism of Action Crofelemer is an inhibitor of both the cyclic adenosine monophosphate (cAMP)-stimulated cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion (Cl¯) channel, and the calcium-activated Cl¯ channels (CaCC) at the luminal membrane of enterocytes. The CFTR Cl¯ channel and CaCC regulate Cl¯ and fluid secretion by intestinal epithelial cells. Crofelemer acts by blocking Cl¯ secretion and accompanying high volume water loss in diarrhea, normalizing the flow of Cl¯ and water in the gastrointestinal tract..

Question 3

What are the most common side effects of CROFELEMER?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for CROFELEMER. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is CROFELEMER the same as MYTESI?

Accepted Answer

MYTESI is a brand name for CROFELEMER. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

CROFELEMER

Mechanism of Action

Indications

FDA Warnings

Known Side Effects

Community Discussions

Primary sources

Compare With

Formulations