What is DALFAMPRIDINE used for?

DALFAMPRIDINE (brand name Dalfampridine) is a Other indicated for 14 )..

What are the most common side effects of DALFAMPRIDINE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for DALFAMPRIDINE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is DALFAMPRIDINE the same as Dalfampridine?

Dalfampridine is a brand name for DALFAMPRIDINE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

DALFAMPRIDINE

Q: How does DALFAMPRIDINE work?

DALFAMPRIDINE works through the following mechanism: 12.1 Mechanism of action The mechanism by which dalfampridine exerts its therapeutic effect has not been fully elucidated. Dalfampridine is a broad spectrum potassium channel blocker. In animal studies, dalfampridine has been shown to increase conduction of action potentials in demyelinated axons through inhibition of potassium channels..

Other

Brand names: Dalfampridine

Oral

Mechanism of Action

12.1 Mechanism of action The mechanism by which dalfampridine exerts its therapeutic effect has not been fully elucidated. Dalfampridine is a broad spectrum potassium channel blocker. In animal studies, dalfampridine has been shown to increase conduction of action potentials in demyelinated axons through inhibition of potassium channels.

Indications

14 ).

FDA Warnings

5 WARNINGS AND PRECAUTIONS Dalfampridine extended-release tablets can cause seizures; the risk of seizures increases with increasing dalfampridine extended-release tablets doses; discontinue dalfampridine extended-release tablets and do not restart if a seizure occurs (5
The risk of seizures in patients with epileptiform activity on an EEG is unknown, and could be substantially higher than that observed in dalfampridine extended-release tablets clinical studies
Dalfampridine extended-release tablets are contraindicated in patients with a history of seizures [see Contraindications (4)]
Because patients with moderate to severe renal impairment (CrCl ≤50mL/min) would require a dose lower than 10 mg twice daily and no strength smaller than 10 mg is available, dalfampridine extended-release tablets are contraindicated in these patients [see Contraindications (4)]

Known Side Effects

9 documented side effects by frequency

Drug Not Working

>10%

Falls

1-10%

Fatigue

1-10%

Dizziness

1-10%

UTI

1-10%

Condition Worsened

0.1-1%

Weakness

0.1-1%

Insomnia

0.1-1%

Headache

0.1-1%

Community Discussions

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Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → DALFAMPRIDINE openFDA label JSON → DALFAMPRIDINE FAERS adverse-event reports → DALFAMPRIDINE ClinicalTrials.gov → completed Phase 2+ trials of DALFAMPRIDINE

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Formulations

Dosage Forms

Tablet

Route

Oral