What are the most common side effects of DARIFENACIN?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for DARIFENACIN. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is DARIFENACIN the same as Darifenacin?

Darifenacin is a brand name for DARIFENACIN. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

DARIFENACIN

Q: What is DARIFENACIN used for?

DARIFENACIN (brand name Darifenacin) is a Anticholinergic (M3 selective) indicated for 1 INDICATIONS AND USAGE Darifenacin extended-release tablets are indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency and frequency. Darifenacin extended-release tablets are a muscarinic antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency and frequency ( 1 ).

Q: How does DARIFENACIN work?

DARIFENACIN works through the following mechanism: 12.1 Mechanism of Action Darifenacin is a competitive muscarinic receptor antagonist. Muscarinic receptors play a role in cholinergically mediated functions, including contractions of the urinary bladder smooth muscle. In vitro studies using human recombinant muscarinic receptor subtypes show that darifenacin has greater affinity for the M 3 receptor than for the other known muscarinic receptors (9- and 12-fold greater affinity for M 3 compared to M 1 and M 5 , respectively, and 59-fold greater affinity for M 3 compared to both M 2 and M 4 ). M 3 receptors are involved in contraction of human bladder..

Anticholinergic (M3 selective)

Brand names: Darifenacin, Enablex

Oral

Mechanism of Action

12.1 Mechanism of Action Darifenacin is a competitive muscarinic receptor antagonist. Muscarinic receptors play a role in cholinergically mediated functions, including contractions of the urinary bladder smooth muscle. In vitro studies using human recombinant muscarinic receptor subtypes show that darifenacin has greater affinity for the M 3 receptor than for the other known muscarinic receptors (9- and 12-fold greater affinity for M 3 compared to M 1 and M 5 , respectively, and 59-fold greater affinity for M 3 compared to both M 2 and M 4 ). M 3 receptors are involved in contraction of human bladder.

Indications

1 INDICATIONS AND USAGE Darifenacin extended-release tablets are indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence

urgency and frequency. Darifenacin extended-release tablets are a muscarinic antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence

urgency and frequency ( 1 )

Contraindications

• 4 CONTRAINDICATIONS Darifenacin extended-release tablets are contraindicated in patients with
• or at risk for
• the following conditions: urinary retention gastric retention
• or uncontrolled narrow-angle glaucoma. Darifenacin extended-release tablets are contraindicated in patients with
• or at risk for

FDA Warnings

5 WARNINGS AND PRECAUTIONS Darifenacin extended-release tablets should be administered with caution to patients with clinically significant bladder outflow obstruction because of the risk of urinary retention ( 5
1 ) Darifenacin extended-release tablets should be administered with caution to patients with gastrointestinal obstructive disorders because of the risk of gastric retention ( 5
2 ) Darifenacin extended-release tablets should be used with caution in patients being treated for narrow-angle glaucoma and only where the potential benefits outweigh the risks ( 5
1 Risk of Urinary Retention Darifenacin extended-release tablets should be administered with caution to patients with clinically significant bladder outflow obstruction because of the risk of urinary retention

Known Side Effects

2 documented side effects by frequency

Drug Not Working

>10%

Joint Pain

1-10%

Community Discussions

5 Reddit threads analysed for DARIFENACIN

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

10 upvotes

Most discussed side effects in community

Anxiety (3)

Fatigue (2)

Dry Mouth (2)

Itching (2)

Patient Experiences (r/pharmacy, r/AskDocs & more)

23 y/o (f) Overactive bladder, truly sad, medications not working... just sharing my story

Hello, This is my first ever reddit post (although I also posted it on the IC subreddit...) I was so inspired by everyone on this thread and I feel I would love answers/ solutions/ thoughts from people here. My symptoms are changing a bit, but the basics are that I just need to pee a lot. all the

r/OveractiveBladder31204y ago

Constant urge to urinate for over a month, but all tests are normal. Has anyone experienced this?

Hi everyone. First, I want to apologize if my English isn’t perfect. It’s not my first language and I used a translator, but I’ll do my best to explain. I’m posting here because I’ve been dealing with something very frustrating for a little over a month and I’m starting to feel really exhausted and

r/PelvicFloor872mo ago

Fatigue

Anxiety

Dry Mouth

23(f) student, Overactive bladder, IC, not loving life. Emselex, Mirabegron, Vesicare.... nothing helps!

Hello, This is my first ever reddit post, I was so inspired by everyone on this thread and I feel I would love answers/ solutions/ thoughts from people here. My symptoms are changing a bit, but the basics are that I just need to pee a lot. all the time. Like, as soon as my bladder is 'empty' I need

r/Interstitialcystitis754y ago

Constant urge to urinate for over a month, but all tests are normal. Has anyone experienced this?

r/Interstitialcystitis4142mo ago

Fatigue

Anxiety

Dry Mouth

Tomorrow I go meet the new Urologist. Has anyone had experience with any of the following medications I will list in the…

Context first, the list of meds I'm inquiring about are under that. So tomorrow I go for my second round, where I meet a new urologist. Last month I went to one, an older man and he ordered a cystoscopy., but when I told him that I feel I need general anesthesia, he laughed and told me I wouldn't

r/Interstitialcystitis222y ago

Anxiety

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → DARIFENACIN openFDA label JSON → DARIFENACIN FAERS adverse-event reports → DARIFENACIN ClinicalTrials.gov → completed Phase 2+ trials of DARIFENACIN

Compare With

4 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral