What is DEFERASIROX used for?

DEFERASIROX (brand name Deferasirox) is a Other indicated for See full prescribing information.

What are the most common side effects of DEFERASIROX?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for DEFERASIROX. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is DEFERASIROX the same as Deferasirox?

Deferasirox is a brand name for DEFERASIROX. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

DEFERASIROX

Q: How does DEFERASIROX work?

DEFERASIROX works through the following mechanism: 12.1 Mechanism of Action Deferasirox is an orally active chelator that is selective for iron (as Fe 3+ ). It is a tridentate ligand that binds iron with high affinity in a 2:1 ratio. Although deferasirox has very low affinity for zinc and copper, there are variable decreases in the serum concentration of these trace metals after the administration of deferasirox. The clinical significance of these decreases is uncertain..

Other

Brand names: Deferasirox

Oral

Mechanism of Action

12.1 Mechanism of Action Deferasirox is an orally active chelator that is selective for iron (as Fe 3+ ). It is a tridentate ligand that binds iron with high affinity in a 2:1 ratio. Although deferasirox has very low affinity for zinc and copper, there are variable decreases in the serum concentration of these trace metals after the administration of deferasirox. The clinical significance of these decreases is uncertain.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS Deferasirox is contraindicated in patients with: Estimated GFR less than 40 mL/min/1.73 m 2 [see Dosage and Administration (2.5)
• Warnings and Precautions (5.1) ]
• Poor performance status [see Warnings and Precautions ( 5.1
• 5.3 )]
• High-risk myelodysplastic syndromes (this patient population was not studied and is not expected to benefit from chelation therapy)

FDA Warnings

5 WARNINGS AND PRECAUTIONS Acute Kidney Injury: Measure serum creatinine in duplicate before starting therapy
2 ) Fatal and Nonfatal Gastrointestinal (GI) Bleeding, Ulceration, and Irritation: Risk may be greater in patients who are taking deferasirox in combination with drugs that have known ulcerogenic or hemorrhagic potential
3 ) Bone Marrow Suppression: Neutropenia, agranulocytosis, worsening anemia, and thrombocytopenia, including fatal events; monitor blood counts during deferasirox therapy
4 ) Age-related Risk of Toxicity: Monitor elderly and pediatric patients closely for toxicity

Known Side Effects

7 documented side effects by frequency

Diarrhea

>10%

Fever

1-10%

Nausea

1-10%

General Unwellness

1-10%

Fatigue

1-10%

Vomiting

0.1-1%

Abdominal Pain

0.1-1%

Community Discussions

No community discussions found for DEFERASIROX yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → DEFERASIROX openFDA label JSON → DEFERASIROX FAERS adverse-event reports → DEFERASIROX ClinicalTrials.gov → completed Phase 2+ trials of DEFERASIROX

Compare With

0 available comparisons

No comparisons yet.

Formulations

Dosage Forms

Tablet

Route

Oral