What is DOXEPIN HYDROCHLORIDE used for?

DOXEPIN HYDROCHLORIDE (brand name Doxepin hydrochloride) is a Tricyclic Antidepressant indicated for 14 ).

What are the most common side effects of DOXEPIN HYDROCHLORIDE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for DOXEPIN HYDROCHLORIDE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is DOXEPIN HYDROCHLORIDE the same as Doxepin hydrochloride?

Doxepin hydrochloride is a brand name for DOXEPIN HYDROCHLORIDE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

DOXEPIN HYDROCHLORIDE

Q: How does DOXEPIN HYDROCHLORIDE work?

DOXEPIN HYDROCHLORIDE works through the following mechanism: 12.1 Mechanism of Action The mechanism of action of doxepin in sleep maintenance is unclear; however, doxepin’s effect could be mediated through antagonism of the H1 receptor..

Tricyclic Antidepressant

Brand names: Doxepin hydrochloride

Oral

Mechanism of Action

12.1 Mechanism of Action The mechanism of action of doxepin in sleep maintenance is unclear; however, doxepin’s effect could be mediated through antagonism of the H1 receptor.

Indications

14 )

Contraindications

• 4 CONTRAINDICATIONS Hypersensitivity to doxepin hydrochloride
• inactive ingredients
• any of its inactive ingredients

FDA Warnings

5 WARNINGS AND PRECAUTIONS Need to Evaluate for Co-morbid Diagnoses: Reevaluate if insomnia persists after 7 to 10 days of use
Although behaviors such as “sleep-driving” may occur with hypnotics alone at therapeutic doses, the use of alcohol and other CNS depressants with hypnotics appears to increase the risk of such behaviors, as does the use of hypnotics at doses exceeding the maximum recommended dose
Due to the risk to the patient and the community, discontinuation of doxepin should be strongly considered for patients who report a “sleep-driving” episode
3 Suicide Risk and Worsening of Depression In primarily depressed patients, worsening of depression, including suicidal thoughts and actions (including completed suicides), has been reported in association with the use of hypnotics

Known Side Effects

11 documented side effects by frequency

Drug Not Working

1-10%

Fatigue

1-10%

Nausea

1-10%

Headache

1-10%

Insomnia

1-10%

Dizziness

1-10%

Itching

1-10%

Anxiety

1-10%

Falls

1-10%

Diarrhea

1-10%

Shortness of Breath

1-10%

Community Discussions

No community discussions found for DOXEPIN HYDROCHLORIDE yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → DOXEPIN HYDROCHLORIDE openFDA label JSON → DOXEPIN HYDROCHLORIDE FAERS adverse-event reports → DOXEPIN HYDROCHLORIDE ClinicalTrials.gov → completed Phase 2+ trials of DOXEPIN HYDROCHLORIDE

Compare With

12 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral