What is DOXERCALCIFEROL used for?

DOXERCALCIFEROL (brand name Doxercalciferol) is a Vitamin / Supplement indicated for See full prescribing information.

What are the most common side effects of DOXERCALCIFEROL?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for DOXERCALCIFEROL. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is DOXERCALCIFEROL the same as Doxercalciferol?

Doxercalciferol is a brand name for DOXERCALCIFEROL. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

DOXERCALCIFEROL

Q: How does DOXERCALCIFEROL work?

DOXERCALCIFEROL works through the following mechanism: 12.1 Mechanism of Action Doxercalciferol is a synthetic vitamin D 2 analog that requires metabolic activation to form the active 1α,25-(OH) 2 D 2 metabolite, which binds to the vitamin D receptor (VDR) to result in the selective activation of vitamin D responsive pathways. Vitamin D and doxercalciferol have been shown to reduce PTH levels by inhibiting PTH synthesis and secretion..

Vitamin / Supplement

Brand names: Doxercalciferol

Oral

Mechanism of Action

12.1 Mechanism of Action Doxercalciferol is a synthetic vitamin D 2 analog that requires metabolic activation to form the active 1α,25-(OH) 2 D 2 metabolite, which binds to the vitamin D receptor (VDR) to result in the selective activation of vitamin D responsive pathways. Vitamin D and doxercalciferol have been shown to reduce PTH levels by inhibiting PTH synthesis and secretion.

Indications

See full prescribing information

Contraindications

• serious hypersensitivity reactions including anaphylaxis and angioedema have been reported [see Warnings and Precautions ( 5.3 )
• Adverse Reactions ( 6.2 )]. Hypercalcemia ( 4 ) Vitamin D toxicity ( 4 ) Know hypersensitivity to doxercalciferol or any of the inactive ingredients of doxercalciferol capsules ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Hypercalcemia: Can occur during treatment with doxercalciferol and can lead to cardiac arrhythmias and seizures
Risk may be increased when used concomitantly with high dose calcium preparations, thiazide diuretics, or vitamin D compounds
1 ) Digitalis Toxicity: Hypercalcemia increases the risk of digitalis toxicity
2 ) Serious Hypersensitivity Reactions: Anaphylaxis, with symptoms of angioedema, hypotension, unresponsiveness, chest discomfort, shortness of breath, and cardiopulmonary arrest, has been reported in hemodialysis patients after administration of doxercalciferol

Known Side Effects

8 documented side effects by frequency

Shortness of Breath

1-10%

Fatigue

1-10%

Vomiting

1-10%

Nausea

1-10%

Anxiety

1-10%

Weakness

1-10%

Chest Pain

0.1-1%

Diarrhea

0.1-1%

Community Discussions

No community discussions found for DOXERCALCIFEROL yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → DOXERCALCIFEROL openFDA label JSON → DOXERCALCIFEROL FAERS adverse-event reports → DOXERCALCIFEROL ClinicalTrials.gov → completed Phase 2+ trials of DOXERCALCIFEROL

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Formulations

Dosage Forms

Tablet

Route

Oral