Brand names: Dupixent
12.1 Mechanism of Action Dupilumab is a human monoclonal IgG4 antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling by specifically binding to the IL-4Rα subunit shared by the IL-4 and IL-13 receptor complexes. Dupilumab inhibits IL-4 signaling via the Type I receptor and both IL-4 and IL-13 signaling through the Type II receptor. Inflammation driven by IL-4 and IL-13 is an important component in the pathogenesis of asthma, AD, CRSwNP, EoE, PN, COPD, CSU, BP, and AFRS. Multiple cell types that express IL-4Rα (e.g., mast cells, basophils, eosinophils, macrophages, lymphocytes, epithelial cells, goblet cells) and inflammatory mediators (e.g., histamine, eicosanoids, leukotrienes, cytokines, chemokines) are involved in inflammation. Blocking IL-4Rα with dupilumab inhibits IL-4 and IL-13 cytokine-induced inflammatory responses, including the release of proinflammatory cytokines, chemokines, nitric oxide, and IgE. The mechanism of dupilumab action has not been def
6 documented side effects by frequency
10 Reddit threads analysed for DUPILUMAB
Overall Sentiment
Mixed
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0
Avg Post Score
108 upvotes
Most discussed side effects in community
disclaimer: eczema is a very individual disease with different causes and triggers for every person. what works for me might not work for you and what didn’t work for me might work for you. just keep that in mind! though i do encourage trying out different things that are not steroids or medical pre
A few years ago, my eczema was severe. I had open weeping wounds all over my body, skin shedding 24/7, no eyebrows, peeling scalp, everything you can imagine. I barely looked human. I'm now 95% normal. I have plenty of scars and hyperpigmentation as a reminder, but aside from random inflammation, I'
So long story short… Big fat eczema flare up. Huge. Spreads over my hands and down my legs. Bleeding when I walk. All over face and chest and cannot leave the house. Call GP, crying my eyes out. Say I’m on the verge of killing myself. Please help me. GP : no, no. Stop crying. STOP CRYING. You won’
I think I honestly just want to rant and talk to some like minded people, maybe those that lead somewhat of a normal life (working, relationships, social interaction) I've suffered severe atopic dermatitis since I was 13, by the time I was 16 it covered every inch of my body and face, during a time
Had severe eczema my entire life (along with severe asthma, yay, severe allergies, yay). Remember back in 2017ish posts about Dupilumab on this forum (and others) from people in the US who were part of the trial saying it was a game changer, as good as steroids (orally, not creams). It got me excite
Sup guys. New here. I (23m) have severe eczema and I've been prescribed everything under the sun: topical steroids, protopic, methotrexate, phototherapy, dupilumab and even homeopathy (my mother is one of those fruitloops, didn't work, ended up in hospital). What I'm saying is that all my mates kind
I've suffered with some really awful eczema for the last 7 years, developing it in middle age. I've been on every oral eczema medication with all the possible side effects, every topical steroid and protopic, tried a very austere diet for 7 months eliminating virtually every possible trigger food.
My dermatologist rang me this morning and told me my application for dupilumab/dupixent got approved and the prescription will be sent to my pharmacy. In my country, I will have to pay €80 a month for a month worth of the drug and the rest is subsidised by the healthcare system. I feel so relieved a
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19 available comparisons
Dosage Forms
Tablet
Route
Subcutaneous