Question 1

What is ELVITEGRAVIR used for?

Accepted Answer

ELVITEGRAVIR (brand name Genvoya) is a Other indicated for an HIV-1 integrase strand transfer inhibitor (INSTI), cobicistat (COBI), a CYP3A inhibitor.

Question 2

How does ELVITEGRAVIR work?

Accepted Answer

ELVITEGRAVIR works through the following mechanism: 12.1 Mechanism of Action GENVOYA is a fixed-dose combination of antiretroviral drugs elvitegravir (plus the CYP3A inhibitor cobicistat), emtricitabine, and tenofovir alafenamide [see Microbiology (12.4) ] . Mechanism of Action Elvitegravir: Elvitegravir inhibits the strand transfer activity of HIV-1 integrase (integrase strand transfer inhibitor; INSTI), an HIV-1 encoded enzyme that is required for viral replication. Inhibition of integrase prevents the integration of HIV-1 DNA into host genomic DNA, blocking the formation of the HIV-1 provirus and propagation of the viral infection. Elvitegravir does not inhibit human topoisomerases I or II. Cobicistat: Cobicistat is a selective, mechanism-based inhibitor of cytochromes P450 of the CYP3A subfamily. Inhibition of CYP3A-mediated metabolism by cobicistat enhances the systemic exposure of CYP3A substrates, such as elvitegravir, where bioavailability is limited and half-life is shortened by CYP3A-dependent metabolism. Emtricitabine: Emtric.

Question 3

What are the most common side effects of ELVITEGRAVIR?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for ELVITEGRAVIR. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is ELVITEGRAVIR the same as Genvoya?

Accepted Answer

Genvoya is a brand name for ELVITEGRAVIR. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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