What are the most common side effects of EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE the same as its brand-name version?

EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE is the generic name. The active ingredient is the same across any brand-name or generic versions approved by the FDA.

EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE

Q: What is EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE used for?

EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE is a SGLT-2 Inhibitor indicated for 1 INDICATIONS AND USAGE SYNJARDY SYNJARDY is a combination of empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor and metformin hydrochloride (HCl) immediate-release, a biguanide.

Q: How does EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE work?

EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE works through the following mechanism: 12.1 Mechanism of Action SYNJARDY or SYNJARDY XR SYNJARDY and SYNJARDY XR contain: empagliflozin, a SGLT2 inhibitor, and metformin HCl, a biguanide. Empagliflozin Empagliflozin is an inhibitor of SGLT2, the predominant transporter responsible for reabsorption of glucose from the glomerular filtrate back into the circulation. By inhibiting SGLT2, empagliflozin reduces renal reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion. Empagliflozin also reduces sodium reabsorption and increases the delivery of sodium to the distal tubule. This may influence several physiological functions including, but not restricted to, increasing tubuloglomerular feedback and reducing intraglomerular pressure, lowering both pre- and afterload of the heart and downregulating sympathetic activity. Metformin HCl Metformin HCl is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes mellitus, lowering b.

SGLT-2 Inhibitor

Oral

Mechanism of Action

12.1 Mechanism of Action SYNJARDY or SYNJARDY XR SYNJARDY and SYNJARDY XR contain: empagliflozin, a SGLT2 inhibitor, and metformin HCl, a biguanide. Empagliflozin Empagliflozin is an inhibitor of SGLT2, the predominant transporter responsible for reabsorption of glucose from the glomerular filtrate back into the circulation. By inhibiting SGLT2, empagliflozin reduces renal reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion. Empagliflozin also reduces sodium reabsorption and increases the delivery of sodium to the distal tubule. This may influence several physiological functions including, but not restricted to, increasing tubuloglomerular feedback and reducing intraglomerular pressure, lowering both pre- and afterload of the heart and downregulating sympathetic activity. Metformin HCl Metformin HCl is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes mellitus, lowering b

Indications

1 INDICATIONS AND USAGE SYNJARDY SYNJARDY is a combination of empagliflozin

a sodium-glucose co-transporter 2 (SGLT2) inhibitor and metformin hydrochloride (HCl) immediate-release

a biguanide

a SGLT2 inhibitor and metformin HCl extended-release

a biguanide

indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus . Empagliflozin Empagliflozin

Contraindications

• including diabetic ketoacidosis [see Warnings and Precautions (5.1) ]. hypersensitivity to empagliflozin
• metformin HCl or any of the excipients in SYNJARDY or SYNJARDY XR
• reactions such as angioedema have occurred [see Warnings and Precautions (5.7) ] . Severe renal impairment (eGFR below 30 mL/min/1.73 m 2 ) ( 4 ) Metabolic acidosis
• including diabetic ketoacidosis ( 4 ) Hypersensitivity to empagliflozin
• metformin HCl or any of the excipients in SYNJARDY or SYNJARDY XR ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Diabetic Ketoacidosis in Patients with Type 1 Diabetes Mellitus and Other Ketoacidosis: Consider ketone monitoring in patients at risk of ketoacidosis, as indicated
4 ) Hypoglycemia: Adult patients taking an insulin secretagogue or insulin may have an increased risk of hypoglycemia
In pediatric patients 10 years of age and older, the risk of hypoglycemia was higher regardless of insulin use
Consider lowering the dosage of insulin secretagogue or insulin to reduce the risk of hypoglycemia when initiating SYNJARDY or SYNJARDY XR

Known Side Effects

10 documented side effects by frequency

Nausea

1-10%

Diarrhea

1-10%

Weight Loss

1-10%

Fatigue

1-10%

Vomiting

1-10%

Dizziness

1-10%

Drug Not Working

1-10%

Shortness of Breath

1-10%

UTI

0.1-1%

Headache

0.1-1%

Community Discussions

4 Reddit threads analysed for EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE

Overall Sentiment

Slightly negative

Comparison Threads

Avg Post Score

7 upvotes

Most discussed side effects in community

Anxiety (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

Recent diagnosis and 3 months progress

Exactly 3 months ago I was diagnosed with diabetes. I felt like my world just exploded, So I turned to the internet to find some incouragment and found this sub. Today I'm sharing my contributions to try providing some encouragement to anyone who diagnosed recently. Diagnosed test A1C 11.3 and fasti

r/diabetes1131y ago

insuline pen tips&tricks?

Hello hello! After a year+ on metformin and Synjardy meds and third covid( or similar virus ) my average blood sugar got pretty high, about 8 minimum to 11 maximum. Even with quite strict diet, so my doc gave me insuline pens, once a day along with pill therapy. However, im new to this and instructi

r/diabetes_t19204y ago

Anyone on Ozempic + Insulin? any issues

I start insulin on Monday. Right now I am on Synjardy and Ozempic. I've lost 25lbs on ozempic, doctor said insulin could make me gain a few. Any experience with this? ty friends.

r/Ozempic5142y ago

Getting Levels Under Control & Feeling worse!

Hey there - (and please note we are communicating with doctor but hearing personal experiences are so helpful, honestly). Curious if others have experiences or feedback to share. My mom is on new medications (Synjardy and even more recent, Januvia) to attempt to get things under control. Her levels

r/diabetes4131y ago

Anxiety

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE openFDA label JSON → EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE FAERS adverse-event reports → EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE ClinicalTrials.gov → completed Phase 2+ trials of EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE

Compare With

3 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral