Question 1

What is ERLOTINIB HYDROCHLORIDE used for?

Accepted Answer

ERLOTINIB HYDROCHLORIDE (brand name Erlotinib) is a Electrolyte / Mineral indicated for maintenance, or second or greater line treatment after progression following at least one prior chemotherapy regimen ( 1.1 ) First-line treatment of patients with locally advanced, unrespectable or metastatic pancreatic cancer.

Question 2

How does ERLOTINIB HYDROCHLORIDE work?

Accepted Answer

ERLOTINIB HYDROCHLORIDE works through the following mechanism: 12.1 Mechanism of Action Epidermal growth factor receptor (EGFR) is expressed on the cell surface of both normal and cancer cells. In some tumor cells signaling through this receptor plays a role in tumor cell survival and proliferation irrespective of EGFR mutation status. Erlotinib reversibly inhibits the kinase activity of EGFR, preventing autophosphorylation of tyrosine residues associated with the receptor and thereby inhibiting further downstream signaling. Erlotinib binding afﬁnity for EGFR exon 19 deletion or exon 21 (L858R) mutations is higher than its afﬁnity for the wild type receptor. Erlotinib inhibition of other tyrosine kinase receptors has not been fully characterized..

Question 3

What are the most common side effects of ERLOTINIB HYDROCHLORIDE?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for ERLOTINIB HYDROCHLORIDE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is ERLOTINIB HYDROCHLORIDE the same as Erlotinib?

Accepted Answer

Erlotinib is a brand name for ERLOTINIB HYDROCHLORIDE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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