Question 1

What is GARADACIMAB used for?

Accepted Answer

GARADACIMAB (brand name ANDEMBRY) is a Other indicated for See full prescribing information.

Question 2

How does GARADACIMAB work?

Accepted Answer

GARADACIMAB works through the following mechanism: 12.1 Mechanism of Action Garadacimab-gxii is an inhibitor of activated FXII that binds to the catalytic domain of activated Factor XII (FXIIa and βFXIIa) and inhibits its catalytic activity. FXII is the first factor activated in the contact activation pathway and initiates the inflammatory bradykinin-producing kallikrein-kinin system. The inhibition of FXIIa decreases the activation of prekallikrein to kallikrein and the generation of bradykinin, which is associated with inflammation and swelling in HAE attacks, thus reducing the cascade of events leading to an HAE attack..

Question 3

What are the most common side effects of GARADACIMAB?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for GARADACIMAB. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is GARADACIMAB the same as ANDEMBRY?

Accepted Answer

ANDEMBRY is a brand name for GARADACIMAB. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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