Question 1

What is IRINOTECAN HYDROCHLORIDE used for?

Accepted Answer

IRINOTECAN HYDROCHLORIDE (brand name Irinotecan Hydrochloride 100 mg/5 mL) is a Chemotherapy indicated for See full prescribing information.

Question 2

How does IRINOTECAN HYDROCHLORIDE work?

Accepted Answer

IRINOTECAN HYDROCHLORIDE works through the following mechanism: 12.1 Mechanism of Action Irinotecan is a derivative of camptothecin. Camptothecins interact specifically with the enzyme topoisomerase I, which relieves torsional strain in DNA by inducing reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks. Current research suggests that the cytotoxicity of irinotecan is due to double-strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topoisomerase I, DNA, and either irinotecan or SN-38. Mammalian cells cannot efficiently repair these double-strand breaks..

Question 3

What are the most common side effects of IRINOTECAN HYDROCHLORIDE?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for IRINOTECAN HYDROCHLORIDE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is IRINOTECAN HYDROCHLORIDE the same as Irinotecan Hydrochloride 100 mg/5 mL?

Accepted Answer

Irinotecan Hydrochloride 100 mg/5 mL is a brand name for IRINOTECAN HYDROCHLORIDE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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