What are the most common side effects of ISONIAZID?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for ISONIAZID. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is ISONIAZID the same as Isoniazid?

Isoniazid is a brand name for ISONIAZID. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

ISONIAZID

Q: What is ISONIAZID used for?

ISONIAZID (brand name Isoniazid) is a Other indicated for INDICATIONS AND USAGE Isoniazid tablets, USP are recommended for all forms of tuberculosis in which organisms are susceptible. However, is inadequate therapy. Isoniazid tablets.

Q: How does ISONIAZID work?

ISONIAZID works through the following mechanism: Mechanism of Action Isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bactericidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms..

Other

Brand names: Isoniazid

Pregnancy: Category COral

Mechanism of Action

Mechanism of Action Isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bactericidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms.

Indications

INDICATIONS AND USAGE Isoniazid tablets

USP are recommended for all forms of tuberculosis in which organisms are susceptible. However

is inadequate therapy. Isoniazid tablets

USP are recommended as preventive therapy for the following groups

therapy should be continued. Recent converters

as indicated by a tuberculin skin test (greater than or equal to 10 mm increase within a 2-year period for those less than 35 years old

Contraindications

• CONTRAINDICATIONS Isoniazid is contraindicated in patients who develop severe hypersensitivity reactions
• including drug-induced hepatitis
• previous isoniazid-associated hepatic injury
• severe adverse reactions to isoniazid such as drug fever
• chills

FDA Warnings

WARNING Severe and sometimes fatal hepatitis associated with isoniazid therapy has been reported and may occur or may develop even after many months of treatment
The risk of developing hepatitis is age related
The risk of hepatitis is increased with daily consumption of alcohol
Precise data to provide a fatality rate for isoniazid-related hepatitis is not available; however, in a U

Known Side Effects

8 documented side effects by frequency

Drug Not Working

>10%

Fever

>10%

Nausea

1-10%

Vomiting

1-10%

Headache

1-10%

Joint Pain

0.1-1%

Diarrhea

0.1-1%

Rash

0.1-1%

Community Discussions

No community discussions found for ISONIAZID yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → ISONIAZID openFDA label JSON → ISONIAZID FAERS adverse-event reports → ISONIAZID ClinicalTrials.gov → completed Phase 2+ trials of ISONIAZID

Compare With

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Formulations

Dosage Forms

Tablet

Route

Oral