Question 1

What is LIFITEGRAST used for?

Accepted Answer

LIFITEGRAST (brand name Xiidra) is a Other indicated for See full prescribing information.

Question 2

How does LIFITEGRAST work?

Accepted Answer

LIFITEGRAST works through the following mechanism: 12.1 Mechanism of Action Lifitegrast binds to the integrin LFA-1, a cell surface protein found on leukocytes and blocks the interaction of LFA-1 with its cognate ligand intercellular adhesion molecule‑1 (ICAM-1). ICAM-1 may be overexpressed in corneal and conjunctival tissues in DED. LFA-1/ICAM-1 interaction can contribute to the formation of an immunological synapse resulting in T‑cell activation and migration to target tissues. In vitro studies demonstrated that lifitegrast may inhibit T-cell adhesion to ICAM-1 in a human T-cell line and may inhibit secretion of inflammatory cytokines in human peripheral blood mononuclear cells. The exact mechanism of action of lifitegrast in DED is not known..

Question 3

What are the most common side effects of LIFITEGRAST?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for LIFITEGRAST. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is LIFITEGRAST the same as Xiidra?

Accepted Answer

Xiidra is a brand name for LIFITEGRAST. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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