What is LINAGLIPTIN AND METFORMIN HYDROCHLORIDE used for?

LINAGLIPTIN AND METFORMIN HYDROCHLORIDE is a DPP-4 Inhibitor indicated for a dipeptidyl peptidase-4 (DPP-4) inhibitor and metformin hydrochloride (HCl), a biguanide.

What are the most common side effects of LINAGLIPTIN AND METFORMIN HYDROCHLORIDE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for LINAGLIPTIN AND METFORMIN HYDROCHLORIDE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is LINAGLIPTIN AND METFORMIN HYDROCHLORIDE the same as its brand-name version?

LINAGLIPTIN AND METFORMIN HYDROCHLORIDE is the generic name. The active ingredient is the same across any brand-name or generic versions approved by the FDA.

LINAGLIPTIN AND METFORMIN HYDROCHLORIDE

Q: How does LINAGLIPTIN AND METFORMIN HYDROCHLORIDE work?

LINAGLIPTIN AND METFORMIN HYDROCHLORIDE works through the following mechanism: 12.1 Mechanism of Action JENTADUETO XR JENTADUETO XR contains: linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin, a biguanide. Linagliptin Linagliptin is an inhibitor of DPP-4, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Thus, linagliptin increases the concentrations of active incretin hormones, stimulating the release of insulin in a glucose-dependent manner and decreasing the levels of glucagon in the circulation. Both incretin hormones are involved in the physiological regulation of glucose homeostasis. Incretin hormones are secreted at a low basal level throughout the day and levels rise immediately after meal intake. GLP-1 and GIP increase insulin biosynthesis and secretion from pancreatic beta cells in the presence of normal and elevated blood glucose levels. Furthermore, GLP-1 also reduces glucagon secretion from pancreatic alpha cells, resulting in a reduction in hepat.

DPP-4 Inhibitor

Oral

Mechanism of Action

12.1 Mechanism of Action JENTADUETO XR JENTADUETO XR contains: linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin, a biguanide. Linagliptin Linagliptin is an inhibitor of DPP-4, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Thus, linagliptin increases the concentrations of active incretin hormones, stimulating the release of insulin in a glucose-dependent manner and decreasing the levels of glucagon in the circulation. Both incretin hormones are involved in the physiological regulation of glucose homeostasis. Incretin hormones are secreted at a low basal level throughout the day and levels rise immediately after meal intake. GLP-1 and GIP increase insulin biosynthesis and secretion from pancreatic beta cells in the presence of normal and elevated blood glucose levels. Furthermore, GLP-1 also reduces glucagon secretion from pancreatic alpha cells, resulting in a reduction in hepat

Indications

a dipeptidyl peptidase-4 (DPP-4) inhibitor and metformin hydrochloride (HCl)

a biguanide

Contraindications

• including diabetic ketoacidosis [see Warnings and Precautions (5.1) ]. hypersensitivity to linagliptin
• metformin
• or any of the excipients in JENTADUETO XR
• reactions such as anaphylaxis
• angioedema

FDA Warnings

5 WARNINGS AND PRECAUTIONS Lactic acidosis: See boxed warning ( 5
1 ) Pancreatitis: There have been reports of acute pancreatitis, including fatal pancreatitis
2 ) Hypoglycemia: Consider lowering the dosage of insulin secretagogue or insulin to reduce the risk of hypoglycemia when initiating JENTADUETO XR
3 ) Hypersensitivity reactions: Serious hypersensitivity reactions (e

Known Side Effects

12 documented side effects by frequency

Diarrhea

1-10%

Nausea

1-10%

Fatigue

1-10%

Shortness of Breath

1-10%

Dizziness

1-10%

Vomiting

1-10%

General Unwellness

1-10%

Headache

1-10%

Joint Pain

1-10%

Itching

1-10%

Drug Not Working

1-10%

Fever

0.1-1%

Community Discussions

7 Reddit threads analysed for LINAGLIPTIN AND METFORMIN HYDROCHLORIDE

Overall Sentiment

Slightly positive

Comparison Threads

Avg Post Score

12,146 upvotes

Most discussed side effects in community

Rash (2)

Vision Changes (2)

Mood Changes (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

TIFU by editing some comments and creating an unnecessary controversy.

**tl;dr:** I fucked up. I ruined Thanksgiving. I’m sorry. I won’t do it again. We are taking a more aggressive stance against toxic users and poorly behaving communities. You can filter r/all now. Hi All, I am sorry: I am sorry for compromising the trust you all have in Reddit, and I am sorry to tho

r/announcements50,313347499y ago

Unlocking GeForce NOW reveals God of War (2018) for PC (Steam) and more

[https://medium.com/@ighor/i-unlocked-nvidia-geforce-now-and-stumbled-upon-pirates-dc48a3f8ff7](https://medium.com/@ighor/i-unlocked-nvidia-geforce-now-and-stumbled-upon-pirates-dc48a3f8ff7) **HERE ARE THE GAMES CONFIRMED SO FAR:** * ''[ActRaiser Remake by Square Enix](https://ibb.co/f8XqCR1)'' [**\

r/GamingLeaksAndRumours9,01718334y ago

Rash

Vision Changes

It’s giveaway time with ASUS!

#Entries are now closed, thank you to everyone for participating. Asus will now choose their winners and we will make another announcement once they've been chosen. #**It’s giveaway time with ASUS!** Hey r/buildapc! We are super excited to announce this giveaway with ASUS, and what better time than

r/buildapc8,549166975y ago

Hi Superstonk! Matthew Ball to talk Metaverse, GameStopverse, Stonkverse, and more! AMA.

**Edit:** Thanks everyone! Gotta sign off after 4 hours, but deeply appreciate everyone's comments and may try to jump in a few tomorrow. Thank you!! Hi everyone. I touched on this a [bit yesterday](https://www.reddit.com/r/Superstonk/comments/ucapbh/comment/i69bxju/?utm_source=share&utm_medium=

r/Superstonk5,0602014y ago

Rash

Vision Changes

Tagged Zebra finch showed up at my feeder in Massachusetts. Do I need to call someone?

**I am NOT the Original Poster. That is** [avokato\_](https://www.reddit.com/user/avokato_/). They posted in r/birding and r/Finches Thanks to u/FunkisHen for the rec! # Do NOT comment on Original Posts. Latest update is 7 days old. **Mood Spoiler:** >!happy ending!!< **Original** [Post](https

r/BestofRedditorUpdates5,0273576mo ago

Mood Changes

This Week At Bungie 8/19/2021

Source: https://www.bungie.net/en/News/Article/50572 --- This week at Bungie, we’re talking weapons. This is it, the last TWAB of the Season. It’s been a blast watching Guardians splice their way through the Vex network, tackle Vault of Glass, and pile up a ton of new rewards during Season of the

r/DestinyTheGame3,72825194y ago

I went on a LAN party with my Steam Deck...

... and it was absolutely amazing! Everyone else had to travel with multiple bags and backpacks, while for me everything fit into one small bag. Plus, I obviously saved a ton of time setting up and tearing down the LAN setup. I originally only wanted to use some XR glasses as a monitor, but the LAN

r/SteamDeck3,3272754mo ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → LINAGLIPTIN AND METFORMIN HYDROCHLORIDE openFDA label JSON → LINAGLIPTIN AND METFORMIN HYDROCHLORIDE FAERS adverse-event reports → LINAGLIPTIN AND METFORMIN HYDROCHLORIDE ClinicalTrials.gov → completed Phase 2+ trials of LINAGLIPTIN AND METFORMIN HYDROCHLORIDE

Compare With

4 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral