How does NALBUPHINE HYDROCHLORIDE work?

NALBUPHINE HYDROCHLORIDE works through the following mechanism: Mechanism of Action Nalbuphine is an agonist at kappa opioid receptors and an antagonist at mµ opioid receptors..

What are the most common side effects of NALBUPHINE HYDROCHLORIDE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for NALBUPHINE HYDROCHLORIDE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is NALBUPHINE HYDROCHLORIDE the same as Nalbuphine Hydrochloride?

Nalbuphine Hydrochloride is a brand name for NALBUPHINE HYDROCHLORIDE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

NALBUPHINE HYDROCHLORIDE

Q: What is NALBUPHINE HYDROCHLORIDE used for?

NALBUPHINE HYDROCHLORIDE (brand name Nalbuphine Hydrochloride) is a Electrolyte / Mineral indicated for for preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery. Limitations of Use: Because of the risks of addiction, abuse.

Electrolyte / Mineral

Brand names: Nalbuphine Hydrochloride

Intramuscular, Intravenous, Subcutaneous

Mechanism of Action

Mechanism of Action Nalbuphine is an agonist at kappa opioid receptors and an antagonist at mµ opioid receptors.

Indications

for preoperative and postoperative analgesia

and for obstetrical analgesia during labor and delivery. Limitations of Use: Because of the risks of addiction

abuse

and misuse with opioids

which can occur at any dosage or duration [see WARNINGS ]

reserve Nalbuphine Hydrochloride Injection for use in patients for whom alternative treatment options (e.g.

Contraindications

• including paralytic ileus [see WARNINGS ] Hypersensitivity to nalbuphine or to any of the other ingredients in Nalbuphine Hydrochloride Injection.

FDA Warnings

WARNING: SERIOUS AND LIFE-THREATENING RISKS FROM USE OF NALBUPHINE HYDROCHLORIDE INJECTION Life-Threatening Respiratory Depression Serious, life-threatening, or fatal respiratory depression may occur with use of Nalbuphine Hydrochloride Injection, especially during initiation or following a dosage increase
To reduce the ‎risk of respiratory depression, proper dosing and titration of ‎‎Nalbuphine Hydrochloride Injection are essential [see WARNINGS ]
Risks From Concomitant Use With Benzodiazepines Or Other CNS Depressants Concomitant use with benzodiazepines and/or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death
Reserve concomitant prescribing of Nalbuphine Hydrochloride Injection and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate [see WARNINGS ; Drug Interactions ]

Known Side Effects

3 documented side effects by frequency

Drug Not Working

1-10%

Itching

0.1-1%

Fever

0.1-1%

Community Discussions

No community discussions found for NALBUPHINE HYDROCHLORIDE yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → NALBUPHINE HYDROCHLORIDE openFDA label JSON → NALBUPHINE HYDROCHLORIDE FAERS adverse-event reports → NALBUPHINE HYDROCHLORIDE ClinicalTrials.gov → completed Phase 2+ trials of NALBUPHINE HYDROCHLORIDE

Compare With

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Formulations

Dosage Forms

Tablet

Route

Intramuscular, Intravenous, Subcutaneous