What is NALOXONE HYDROCHLORIDE used for?

NALOXONE HYDROCHLORIDE (brand name NALOXONE HYDROCHLORIDE) is a Substance Use Agent indicated for 1 INDICATIONS AND USAGE Naloxone HCl Nasal Spray is indicated for the emergency treatment of known or suspected opioid overdose.

What are the most common side effects of NALOXONE HYDROCHLORIDE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for NALOXONE HYDROCHLORIDE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is NALOXONE HYDROCHLORIDE the same as NALOXONE HYDROCHLORIDE?

NALOXONE HYDROCHLORIDE is a brand name for NALOXONE HYDROCHLORIDE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

NALOXONE HYDROCHLORIDE

Q: How does NALOXONE HYDROCHLORIDE work?

NALOXONE HYDROCHLORIDE works through the following mechanism: 12.1 Mechanism of Action Naloxone hydrochloride is an opioid antagonist that antagonizes opioid effects by competing for the same receptor sites. Naloxone hydrochloride reverses the effects of opioids, including respiratory depression, sedation, and hypotension. It can also reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine..

Substance Use Agent

Brand names: NALOXONE HYDROCHLORIDE, Narcan, Evzio

Nasal

Mechanism of Action

12.1 Mechanism of Action Naloxone hydrochloride is an opioid antagonist that antagonizes opioid effects by competing for the same receptor sites. Naloxone hydrochloride reverses the effects of opioids, including respiratory depression, sedation, and hypotension. It can also reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.

Indications

1 INDICATIONS AND USAGE Naloxone HCl Nasal Spray is indicated for the emergency treatment of known or suspected opioid overdose

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Risk of Recurrent Respiratory and CNS Depression: Due to the duration of action of naloxone relative to the opioid, keep patient under continued surveillance and administer repeat doses of naloxone using a new nasal spray with each dose, as necessary, while awaiting emergency medical assistance
1 ) • Risk of Limited Efficacy with Partial Agonists or Mixed Agonists/Antagonists: Reversal of respiratory depression caused by partial agonists or mixed agonists/antagonists, such as buprenorphine and pentazocine, may be incomplete
3 ) • Risk of Cardiovascular (CV) Effects: Abrupt postoperative reversal of opioid depression may result in adverse CV effects
1 Risk of Recurrent Respiratory and Central Nervous System Depression The duration of action of most opioids may exceed that of Naloxone HCl Nasal Spray resulting in a return of respiratory and/or central nervous system depression after an initial improvement in symptoms

Known Side Effects

7 documented side effects by frequency

Nausea

1-10%

Vomiting

1-10%

Anxiety

1-10%

Headache

0.1-1%

Drug Not Working

0.1-1%

Fatigue

0.1-1%

Insomnia

0.1-1%

Community Discussions

No community discussions found for NALOXONE HYDROCHLORIDE yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → NALOXONE HYDROCHLORIDE openFDA label JSON → NALOXONE HYDROCHLORIDE FAERS adverse-event reports → NALOXONE HYDROCHLORIDE ClinicalTrials.gov → completed Phase 2+ trials of NALOXONE HYDROCHLORIDE

Compare With

6 available comparisons

Formulations

Dosage Forms

Tablet

Route

Nasal