Brand names: Nefazodone Hydrochloride
Pharmacodynamics The mechanism of action of nefazodone, as with other antidepressants, is unknown. Preclinical studies have shown that nefazodone inhibits neuronal uptake of serotonin and norepinephrine. Nefazodone occupies central 5-HT 2 receptors at nanomolar concentrations, and acts as an antagonist at this receptor. Nefazodone was shown to antagonize alpha 1 -adrenergic receptors, a property which may be associated with postural hypotension. In vitro binding studies showed that nefazodone ha
Contraindications
7 documented side effects by frequency
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7 available comparisons
Dosage Forms
Tablet
Route
Oral