Question 1

What is NELARABINE used for?

Accepted Answer

NELARABINE (brand name NELARABINE) is a Other indicated for See full prescribing information.

Question 2

How does NELARABINE work?

Accepted Answer

NELARABINE works through the following mechanism: 12.1 Mechanism of Action Nelarabine is a prodrug of the deoxyguanosine analogue 9-β- D -arabinofuranosylguanine (ara-G), a nucleoside metabolic inhibitor. Nelarabine is demethylated by adenosine deaminase (ADA) to ara-G, mono-phosphorylated by deoxyguanosine kinase and deoxycytidine kinase, and subsequently converted to the active 5’-triphosphate, ara-GTP. Accumulation of ara-GTP in leukemic blasts allows for incorporation into deoxyribonucleic acid (DNA), leading to inhibition of DNA synthesis and cell death. Other mechanisms may contribute to the cytotoxic and systemic toxicity of nelarabine..

Question 3

What are the most common side effects of NELARABINE?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for NELARABINE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is NELARABINE the same as NELARABINE?

Accepted Answer

NELARABINE is a brand name for NELARABINE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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