Brand names: Striverdi Respimat
12.1 Mechanism of Action Olodaterol is a long-acting beta 2 -adrenergic agonist (LABA). The compound exerts its pharmacological effects by binding and activation of beta 2 -adrenoceptors after topical administration by inhalation. Activation of these receptors in the airways results in a stimulation of intracellular adenyl cyclase, an enzyme that mediates the synthesis of cyclic-3', 5' adenosine monophosphate (cAMP). Elevated levels of cAMP induce bronchodilation by relaxation of airway smooth muscle cells. In vitro studies have shown that olodaterol has 241-fold greater agonist activity at beta 2 -adrenoceptors compared to beta 1 -adrenoceptors and 2,299-fold greater agonist activity compared to beta 3 -adrenoceptors. The clinical significance of these findings is unknown. Beta-adrenoceptors are divided into three subtypes: beta 1 -adrenoceptors predominantly expressed on cardiac smooth muscle, beta 2 -adrenoceptors predominantly expressed on airway smooth muscle, and beta 3 -adrenoce
Contraindications
9 documented side effects by frequency
2 Reddit threads analysed for OLODATEROL RESPIMAT INHALATION SPRAY
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
12 upvotes
Hello all, I'm working on updating my hospital's formulary and I have a question about Spiriva Respimat dosing for both COPD and asthma. My drug references (namely Lexicomp and Micromedex) say to give 2 inhalations of the 1.25 mcg Respimat for asthma and 2 inhalations of the 2.5 mcg Respimat for COP
I just got a refill on my Pro-Air rescue inhaler. I've been using them for years. When I was priming it, I noticed that the medication seemed to be spraying out a lot more forcibly, comparable to the old ozone destroying CFC Albuterol inhalers. Am I just seeing things, or did the manufacturer recent
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Every figure on this page links back to its primary source. See data sources for full provenance.
0 available comparisons
No comparisons yet.
Dosage Forms
Tablet
Route
Respiratory (inhalation)