What is PALIPERIDONE used for?

PALIPERIDONE (brand name Paliperidone) is a Atypical Antipsychotic indicated for as well as one maintenance trial in adults..

What are the most common side effects of PALIPERIDONE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for PALIPERIDONE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is PALIPERIDONE the same as Paliperidone?

Paliperidone is a brand name for PALIPERIDONE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

PALIPERIDONE

Q: How does PALIPERIDONE work?

PALIPERIDONE works through the following mechanism: 12.1 Mechanism of Action Paliperidone is the major active metabolite of risperidone. The mechanism of action of paliperidone in schizophrenia is unclear. However, the drug's therapeutic effect in schizophrenia could be mediated through a combination of central dopamine Type 2 (D 2 ) and serotonin Type 2 (5HT 2A ) receptor antagonism..

Atypical Antipsychotic

Brand names: Paliperidone, Invega

Oral

Mechanism of Action

12.1 Mechanism of Action Paliperidone is the major active metabolite of risperidone. The mechanism of action of paliperidone in schizophrenia is unclear. However, the drug's therapeutic effect in schizophrenia could be mediated through a combination of central dopamine Type 2 (D 2 ) and serotonin Type 2 (5HT 2A ) receptor antagonism.

Indications

as well as one maintenance trial in adults.

Contraindications

• 4 CONTRAINDICATIONS Paliperidone extended-release tablets are contraindicated in patients with a known hypersensitivity to either paliperidone or risperidone
• or to any of the excipients in the paliperidone extended-release tablet formulation. Hypersensitivity reactions
• including anaphylactic reactions and angioedema
• have been reported in patients treated with risperidone and in patients treated with paliperidone. Paliperidone is a metabolite of risperidone. Known hypersensitivity to paliperidone
• risperidone

FDA Warnings

5 WARNINGS AND PRECAUTIONS Cerebrovascular Adverse Reactions: An increased incidence of cerebrovascular adverse reactions (e
, stroke, transient ischemic attack, including fatalities) has been seen in elderly patients with dementia-related psychoses treated with atypical antipsychotics
3) QT Prolongation: Increase in QT interval, avoid use with drugs that also increase QT interval and in patients with risk factors for prolonged QT interval
5) Metabolic Changes: Atypical antipsychotic drugs have been associated with metabolic changes that may increase cardiovascular/cerebrovascular risk

Known Side Effects

3 documented side effects by frequency

Drug Not Working

>10%

Weight Gain

1-10%

Condition Worsened

0.1-1%

Community Discussions

No community discussions found for PALIPERIDONE yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → PALIPERIDONE openFDA label JSON → PALIPERIDONE FAERS adverse-event reports → PALIPERIDONE ClinicalTrials.gov → completed Phase 2+ trials of PALIPERIDONE

Compare With

19 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral