How does QUINIDINE GLUONATE work?

QUINIDINE GLUONATE works through the following mechanism: Other agent.

What are the most common side effects of QUINIDINE GLUONATE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for QUINIDINE GLUONATE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is QUINIDINE GLUONATE the same as Quinidine gluconate?

Quinidine gluconate is a brand name for QUINIDINE GLUONATE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

QUINIDINE GLUONATE

Q: What is QUINIDINE GLUONATE used for?

QUINIDINE GLUONATE (brand name Quinidine gluconate) is a Other indicated for generally patients who have had previous episodes of atrial fibrillation/flutter that were so frequent and poorly tolerated as to outweigh, in the judgment of the physician and the patient, the risks of prophylactic therapy with quinidine gluconate. The increased risk of death should specifically be considered. Quinidine gluconate should be used only after alternative measures (e.g..

Other

Brand names: Quinidine gluconate, NUEDEXTA

Oral

Mechanism of Action

Other agent

Indications

generally patients who have had previous episodes of atrial fibrillation/flutter that were so frequent and poorly tolerated as to outweigh

in the judgment of the physician and the patient

the risks of prophylactic therapy with quinidine gluconate. The increased risk of death should specifically be considered. Quinidine gluconate should be used only after alternative measures (e.g.

use of other drugs to control the ventricular rate) have been found to be inadequate. In patients with histories of frequent symptomatic episodes of atrial fibrillation/flutter

the goal of therapy should be an increase in the average time between episodes. In most patients

the tachyarrhythmia will recur during therapy

Contraindications

• CONTRAINDICATIONS Quinidine is contraindicated in patients who are known to be allergic to it
• quinidine is also contraindicated in any patient whose cardiac rhythm is dependent upon a junctional or idioventricular pacemaker
• including patients in complete atrioventricular block. Quinidine is also contraindicated in patients who
• like those with myasthenia gravis
• might be adversely affected by an anticholinergic agent.

FDA Warnings

WARNINGS Mortality: In many trials of antiarrhythmic therapy for non-life-threatening arrhythmias, active antiarrhythmic therapy has resulted in increased mortality; the risk of active therapy is probably greatest in patients with structural heart disease
The risk of torsades is increased by bradycardia, hypokalemia, hypomagnesemia or high serum levels of quinidine, but it may appear in the absence of any of these risk factors
A case control study found a 125-fold increased risk of severe thrombocytopenia (platelets<30,000 μL, requiring hospitalization) with quinidine
Patients should have risk/benefit re-evaluated in order to continue treatment with quinidine

Known Side Effects

8 documented side effects by frequency

Falls

1-10%

Drug Not Working

1-10%

Dizziness

1-10%

Fatigue

1-10%

Diarrhea

1-10%

Nausea

1-10%

Drowsiness

0.1-1%

Depression

0.1-1%

Community Discussions

No community discussions found for QUINIDINE GLUONATE yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → QUINIDINE GLUONATE openFDA label JSON → QUINIDINE GLUONATE FAERS adverse-event reports → QUINIDINE GLUONATE ClinicalTrials.gov → completed Phase 2+ trials of QUINIDINE GLUONATE

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Formulations

Dosage Forms

Tablet

Route

Oral