What are the most common side effects of RIFAMPIN?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for RIFAMPIN. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is RIFAMPIN the same as Rifadin IV?

Rifadin IV is a brand name for RIFAMPIN. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

RIFAMPIN

Q: What is RIFAMPIN used for?

RIFAMPIN (brand name Rifadin IV) is a Other indicated for INDICATIONS AND USAGE In the treatment of both tuberculosis and the meningococcal carrier state, the drug regimen should be modified. Tuberculosis Rifampin is indicated in the treatment of all forms of tuberculosis. A three-drug regimen consisting of rifampin, isoniazid.

Q: How does RIFAMPIN work?

RIFAMPIN works through the following mechanism: Mechanism of Action Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible Mycobacterium tuberculosis organisms. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme..

Other

Brand names: Rifadin IV

Intravenous

Mechanism of Action

Mechanism of Action Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible Mycobacterium tuberculosis organisms. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.

Indications

INDICATIONS AND USAGE In the treatment of both tuberculosis and the meningococcal carrier state

the drug regimen should be modified. Tuberculosis Rifampin is indicated in the treatment of all forms of tuberculosis. A three-drug regimen consisting of rifampin

isoniazid

and pyrazinamide is recommended in the initial phase of short-course therapy which is usually continued for 2 months. The Advisory Council for the Elimination of Tuberculosis

the American Thoracic Society

and Centers for Disease Control and Prevention recommend that either streptomycin or ethambutol be added as a fourth drug in a regimen containing isoniazid (INH)

Contraindications

• CONTRAINDICATIONS RIFADIN is contraindicated in patients with a history of hypersensitivity to rifampin or any of the components
• Drug Interactions .) Rifampin is contraindicated in patients who are also receiving atazanavir
• darunavir
• fosamprenavir
• saquinavir

FDA Warnings

WARNINGS Hepatotoxicity of hepatocellular, cholestatic, and mixed patterns has been reported in patients treated with rifampin
Severity ranged from asymptomatic elevations in liver enzymes, isolated jaundice/hyperbilirubinemia, symptomatic self-limited hepatitis to fulminant liver failure and death
Severe hepatic dysfunction including fatalities were reported in patients with liver disease and in patients taking rifampin with other hepatotoxic agents
Monitor coagulation tests during rifampin treatment (prothrombin time and other coagulation tests) in patients at risk of vitamin K deficiency (such as those with chronic liver disease, poor nutritional status, on prolonged antibacterial drugs or anticoagulants)

Known Side Effects

8 documented side effects by frequency

Drug Not Working

>10%

Nausea

1-10%

Condition Worsened

1-10%

Fever

1-10%

Vomiting

0.1-1%

Shortness of Breath

0.1-1%

Rash

0.1-1%

Diarrhea

0.1-1%

Community Discussions

No community discussions found for RIFAMPIN yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → RIFAMPIN openFDA label JSON → RIFAMPIN FAERS adverse-event reports → RIFAMPIN ClinicalTrials.gov → completed Phase 2+ trials of RIFAMPIN

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Formulations

Dosage Forms

Tablet

Route

Intravenous