Question 1

What is ROMIDEPSIN used for?

Accepted Answer

ROMIDEPSIN (brand name ISTODAX) is a Other indicated for See full prescribing information.

Question 2

How does ROMIDEPSIN work?

Accepted Answer

ROMIDEPSIN works through the following mechanism: 12.1 Mechanism of Action Romidepsin is a histone deacetylase (HDAC) inhibitor. HDACs catalyze the removal of acetyl groups from acetylated lysine residues in histones, resulting in the modulation of gene expression. HDACs also deacetylate non-histone proteins, such as transcription factors. In vitro, romidepsin causes the accumulation of acetylated histones, and induces cell cycle arrest and apoptosis of some cancer cell lines with IC 50 values in the nanomolar range. The mechanism of the antineoplastic effect of romidepsin observed in nonclinical and clinical studies has not been fully characterized..

Question 3

What are the most common side effects of ROMIDEPSIN?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for ROMIDEPSIN. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is ROMIDEPSIN the same as ISTODAX?

Accepted Answer

ISTODAX is a brand name for ROMIDEPSIN. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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