Question 1

What is SALMETEROL XINAFOATE used for?

Accepted Answer

SALMETEROL XINAFOATE (brand name SEREVENT DISKUS) is a Beta-2 Agonist Bronchodilator indicated for including patients with symptoms of nocturnal asthma. LABA, such as salmeterol, the active ingredient in SEREVENT DISKUS.

Question 2

How does SALMETEROL XINAFOATE work?

Accepted Answer

SALMETEROL XINAFOATE works through the following mechanism: 12.1 Mechanism of Action Salmeterol is a selective LABA. In vitro studies show salmeterol to be at least 50 times more selective for beta 2 -adrenoceptors than albuterol. Although beta 2 -adrenoceptors are the predominant adrenergic receptors in bronchial smooth muscle and beta 1 -adrenoceptors are the predominant receptors in the heart, there are also beta 2 -adrenoceptors in the human heart comprising 10% to 50% of the total beta-adrenoceptors. The precise function of these receptors has not been established, but their presence raises the possibility that even selective beta 2 -agonists may have cardiac effects. The pharmacologic effects of beta 2 -adrenoceptor agonist drugs, including salmeterol, are at least in part attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3′,5′-adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibi.

Question 3

What are the most common side effects of SALMETEROL XINAFOATE?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for SALMETEROL XINAFOATE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is SALMETEROL XINAFOATE the same as SEREVENT DISKUS?

Accepted Answer

SEREVENT DISKUS is a brand name for SALMETEROL XINAFOATE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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