Question 1

What is SEBETRALSTAT used for?

Accepted Answer

SEBETRALSTAT (brand name EKTERLY) is a Other indicated for See full prescribing information.

Question 2

How does SEBETRALSTAT work?

Accepted Answer

SEBETRALSTAT works through the following mechanism: 12.1 Mechanism of Action Sebetralstat is a competitive, reversible inhibitor of plasma kallikrein. Plasma kallikrein is a serine protease that cleaves high molecular weight kininogen (HK) releasing bradykinin which increases vascular permeability through activation of bradykinin receptors causing edema. Sebetralstat inhibits the cleavage of HK and reduces production of bradykinin, thereby treating the clinical symptoms of an acute, episodic attack of HAE. Sebetralstat also inhibits the positive feedback mechanism of the kallikrein kinin system by plasma kallikrein, thereby reducing factor XIIa and additional plasma kallikrein generation..

Question 3

What are the most common side effects of SEBETRALSTAT?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for SEBETRALSTAT. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is SEBETRALSTAT the same as EKTERLY?

Accepted Answer

EKTERLY is a brand name for SEBETRALSTAT. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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