What is SOLRIAMFETOL used for?

SOLRIAMFETOL (brand name SUNOSI) is a Other indicated for See full prescribing information.

What are the most common side effects of SOLRIAMFETOL?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for SOLRIAMFETOL. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is SOLRIAMFETOL the same as SUNOSI?

SUNOSI is a brand name for SOLRIAMFETOL. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

SOLRIAMFETOL

Q: How does SOLRIAMFETOL work?

SOLRIAMFETOL works through the following mechanism: 12.1 Mechanism of Action The mechanism of action of solriamfetol to improve wakefulness in patients with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea is unclear. However, its efficacy could be mediated through its activity as a dopamine and norepinephrine reuptake inhibitor (DNRI)..

Other

Brand names: SUNOSI

Oral

Mechanism of Action

12.1 Mechanism of Action The mechanism of action of solriamfetol to improve wakefulness in patients with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea is unclear. However, its efficacy could be mediated through its activity as a dopamine and norepinephrine reuptake inhibitor (DNRI).

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS SUNOSI is contraindicated in patients receiving concomitant treatment with monoamine oxidase (MAO) inhibitors
• or within 14 days following discontinuation of monoamine oxidase inhibitor
• because of the risk of hypertensive reaction [see Drug Interactions ( 7.1 )] . Concurrent treatment with a monoamine oxidase inhibitor (MAOI) or use of an MAOI within the preceding 14 days. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Blood Pressure and Heart Rate Increases : Measure heart rate and blood pressure prior to initiating and periodically throughout treatment
Avoid use in patients with unstable cardiovascular disease, serious heart arrhythmias, or other serious heart problems
Epidemiological data show that chronic elevations in blood pressure increase the risk of major adverse cardiovascular events (MACE), including stroke, heart attack, and cardiovascular death
The magnitude of the increase in absolute risk is dependent on the increase in blood pressure and the underlying risk of MACE in the population being treated

Known Side Effects

10 documented side effects by frequency

Drug Not Working

>10%

Anxiety

1-10%

Headache

1-10%

Nausea

1-10%

Fatigue

1-10%

Drowsiness

1-10%

Depression

0.1-1%

Dizziness

0.1-1%

Insomnia

0.1-1%

High Blood Pressure

0.1-1%

Community Discussions

No community discussions found for SOLRIAMFETOL yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → SOLRIAMFETOL openFDA label JSON → SOLRIAMFETOL FAERS adverse-event reports → SOLRIAMFETOL ClinicalTrials.gov → completed Phase 2+ trials of SOLRIAMFETOL

Compare With

0 available comparisons

No comparisons yet.

Formulations

Dosage Forms

Tablet

Route

Oral