Question 1

What is SPIRONOLACTONE used for?

Accepted Answer

SPIRONOLACTONE (brand name Spironolactone) is a Aldosterone Antagonist indicated for 1 INDICATIONS AND USAGE Spironolactone is an aldosterone antagonist indicated for: The treatment of NYHA Class III-IV heart failure and reduced ejection fraction to increase survival, manage edema, and to reduce the need for hospitalization for heart failure ( 1.1 ). Use as an add-on therapy for the treatment of hypertension.

Question 2

How does SPIRONOLACTONE work?

Accepted Answer

SPIRONOLACTONE works through the following mechanism: 12.1 Mechanism of Action Spironolactone and its active metabolites are specific pharmacologic antagonists of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Spironolactone causes increased amounts of sodium and water to be excreted, while potassium is retained. Spironolactone acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents that act more proximally in the renal tubule..

Question 3

What are the most common side effects of SPIRONOLACTONE?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for SPIRONOLACTONE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is SPIRONOLACTONE the same as Spironolactone?

Accepted Answer

Spironolactone is a brand name for SPIRONOLACTONE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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