Brand names: Sumatriptan, Imitrex
12.1 Mechanism of Action Sumatriptan binds with high affinity to human cloned 5-HT 1B/1D receptors. Sumatriptan presumably exerts its therapeutic effects in the treatment of migraine and cluster headaches through agonist effects at the 5-HT 1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system, which result in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release.
Contraindications
12 documented side effects by frequency
11 Reddit threads analysed for SUMATRIPTAN
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
96 upvotes
Most discussed side effects in community
Like many of you, I suffer from migraines on a regular basis. First it was once a month, then twice a month. This year it was 2-3 times a week and seriously affected my ability to work and spend time with my kids/family. It landed me in the ER twice due to severe vomiting and dehydration. (the ER it
I have chronic migraines along with my epilepsy. I was having around 20 migraines a month but on Emgality they've gone down a lot and the severity is so much more manageable. For the last 4ish years, if I had a horrible migraine attack I'd take my Sumatriptan with some benedryl and it'd usually kil
Hello Im new to the whole epilepsy thing (kinda).(SORRY IF THIS IS LONG) I had seizures from 10wks -2 y/o. Then didnt have another seizure til college (19), was told it could be a fluke, sleep dep. and stress. I went on medication for 2 years and was taken off of it fine for 6 more years. I was comp
I get migraines/headaches. I have 2 kinda similar genres of headache. One is pretty much the same as pre-epilepsy. It's got a distinct stabbing sensation in the side of my head, I can usually stop it or dull it with over-the-counter analgesics (particularly Advil 2). The other one started appearing
i think i'm epileptic. since january, i've been suffering with migraines and i've been to the doctor who prescribed me sumatriptan, which did absolutely nothing. for years, i've been having seizure-like symptoms and my migraines have auras. is this worth checking out? i honestly feel like something
Hi all, I'm 26F and had my first seizure a week ago. I'm wondering if it could be due to serotonin toxicity. I was taking 40 mg Prozac, 300 mg Wellbutrin, 50 mg Sumatriptan (as needed, up to 4/day 2 hours apart), and 8 mg Ondansetron (as needed, up to 2/day). All of these drugs increase serotonin, a
My sis has recently gotten a prescription for sumatriptan for migraines because her last seizure was preceded by a headache. We aren't sure if the headache caused the seizure or if she had a seizure already the night before (no one was around or witnessed how she slept that night). Anyways i just w
When I have seizures I often get severe headaches. I often have to take sumatriptan to get them under control. But now I'm getting headaches every day about the same time the second med dose is due. I take epilepsy meds twice a day. I sometimes go through periods where I get auras just as the meds
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17 available comparisons
Dosage Forms
Tablet
Route
Subcutaneous