What is TAFENOQUINE SUCCINATE used for?

TAFENOQUINE SUCCINATE (brand name Krintafel) is a Other indicated for 5.6 ).

How does TAFENOQUINE SUCCINATE work?

TAFENOQUINE SUCCINATE works through the following mechanism: 12.1 Mechanism of Action Tafenoquine is an 8-aminoquinoline antimalarial drug [see Microbiology ( 12.4 )]..

What are the most common side effects of TAFENOQUINE SUCCINATE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for TAFENOQUINE SUCCINATE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is TAFENOQUINE SUCCINATE the same as Krintafel?

Krintafel is a brand name for TAFENOQUINE SUCCINATE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

TAFENOQUINE SUCCINATE

Other

Brand names: Krintafel

Oral

Mechanism of Action

12.1 Mechanism of Action Tafenoquine is an 8-aminoquinoline antimalarial drug [see Microbiology ( 12.4 )].

Indications

5.6 )

Contraindications

• other 8-aminoquinolines
• 8.2 ) • Known hypersensitivity reactions to tafenoquine
• other 8-aminoquinolines
• or any component of KRINTAFEL. ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Hemolytic Anemia : G6PD testing must be performed before prescribing KRINTAFEL due to the risk of hemolytic anemia
A G6PD-deficient infant may be at risk for hemolytic anemia from exposure to KRINTAFEL through breast milk
3 ) • Psychiatric Effects : Serious psychiatric adverse reactions have been observed in patients with a previous history of psychiatric conditions at doses higher than the approved dose
The benefit of treatment with KRINTAFEL must be weighed against the potential risk for psychiatric adverse reactions in patients with a history of psychiatric illness

Known Side Effects

6 documented side effects by frequency

Depression

>10%

Anxiety

1-10%

Nausea

1-10%

Ringing in Ears

1-10%

Headache

1-10%

Dizziness

1-10%

Community Discussions

No community discussions found for TAFENOQUINE SUCCINATE yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → TAFENOQUINE SUCCINATE openFDA label JSON → TAFENOQUINE SUCCINATE FAERS adverse-event reports → TAFENOQUINE SUCCINATE ClinicalTrials.gov → completed Phase 2+ trials of TAFENOQUINE SUCCINATE

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Formulations

Dosage Forms

Tablet

Route

Oral