Question 1

What is TALAZOPARIB used for?

Accepted Answer

TALAZOPARIB (brand name Talzenna) is a Other indicated for 1 INDICATIONS AND USAGE TALZENNA is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated for: Breast Cancer • As a single agent.

Question 2

How does TALAZOPARIB work?

Accepted Answer

TALAZOPARIB works through the following mechanism: 12.1 Mechanism of Action Talazoparib is an inhibitor of PARP enzymes, including PARP1 and PARP2, which play a role in DNA repair. In vitro studies with cancer cell lines that harbored defects in DNA repair genes, including BRCA1 and BRCA2 , have shown that talazoparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, decreased cell proliferation, and apoptosis. Talazoparib anti-tumor activity was observed in patient-derived xenograft breast cancer models bearing mutated BRCA1 or mutated BRCA2 or wild type BRCA1 and BRCA2 ..

Question 3

What are the most common side effects of TALAZOPARIB?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for TALAZOPARIB. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is TALAZOPARIB the same as Talzenna?

Accepted Answer

Talzenna is a brand name for TALAZOPARIB. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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